ArticleGenes & development2015
Histone modifications predispose genome regions to breakage and translocation.
Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Integration of epigenetics into ecotoxicology: insights and fundamental research needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- DNA damage reduces heterogeneity and coherence of chromatin motions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Demystifying extrachromosomal DNA circles: Categories, biogenesis, and cancer therapeutics.Computational and structural biotechnology journal · 2022Review
- The Role of Polycomb Group Protein BMI1 in DNA Repair and Genomic Stability.International journal of molecular sciences · 2021Review
- A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells.Cellular and molecular life sciences : CMLS · 2020Review
- Understanding intrinsic hematopoietic stem cell aging.Haematologica · 2020Review
- Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity.Stem cell reports · 2019Article
- Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications.Frontiers in oncology · 2019Review
- Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair.PLoS biology · 2018Article
- Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes.Epigenomics · 2018Article
- Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging.Current stem cell reports · 2018Article
- Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer.International journal of molecular sciences · 2018Review
- Nucleosome stability measured in situ by automated quantitative imaging.Scientific reports · 2017Article
- High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease.Trends in genetics : TIG · 2017Review
- Control of structure-specific endonucleases to maintain genome stability.Nature reviews. Molecular cell biology · 2017Review
- SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches.Cold Spring Harbor symposia on quantitative biology · 2017Article
- Accumulation of DNA damage in the aged hematopoietic stem cell compartment.Seminars in hematology · 2017Review
- Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.Trends in molecular medicine · 2016Review
- A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin.Genes & development · 2016Article
- Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences.Nucleic acids research · 2016Article
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
Chromosome translocations are well-established hallmarks of cancer cells and often occur at nonrandom sites in the genome. The molecular features that define recurrent chromosome breakpoints are largely unknown. Using a combination of bioinformatics, biochemical analysis, and cell-based assays, we identify here specific histone modifications as facilitators of chromosome breakage and translocations. We show enrichment of several histone modifications over clinically relevant translocation-prone genome regions. Experimental modulation of histone marks sensitizes genome regions to breakage by endonuclease challenge or irradiation and promotes formation of chromosome translocations of endogenous gene loci. Our results demonstrate that histone modifications predispose genome regions to chromosome breakage and translocations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.