Evidence map›Paper›PMID 26104458›Full record

ReviewMicrobiology spectrum2014

V(D)J Recombination: Mechanism, Errors, and Fidelity.

David B Roth

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology spectrum, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 136 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Revised Adaptive Immune Receptor Data in the Immune Epitope Database.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. A temporal and spatial atlas of adaptive immune responses in the lymph node following viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Cutting-edge technologies in neural regeneration.Cell regeneration (London, England) · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David B RothDepartment of Pathology and Laboratory Medicine and the Center for Personalized Diagnostics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
University of Pennsylvania · US

Funding

RAG-induced DNA damage: mechanisms and responsesR01CA104588 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROTH, DAVID B. · 2004 to 2014
$2.8M
NCI NIH HHS R01 CA104588
6 · The paper itself

Abstract

V(D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation. Here we review the basic aspects of V(D)J recombination, mechanisms underlying aberrant DNA rearrangements, and the types of aberrant events uncovered in recent genomewide analyses of lymphoid neoplasms.

Indexed as

V(D)J RecombinationAnimalsGenetic VariationHumansReceptors, AntigenVDJ RecombinasesReceptors, AntigenVDJ Recombinases

Identifiers

PMID26104458
PMCPMC5089068
OpenAlexW926901942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.