ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
The effects of perturbed cerebral blood flow and cerebrovascular reactivity on structural MRI and behavioral readouts in mild traumatic brain injury.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience.Experimental brain research · 2024Article
- Treatment with the vascular endothelial growth factor-A antibody, bevacizumab, has sex-specific effects in a rat model of mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Treatment with vascular endothelial growth factor-A worsens cognitive recovery in a rat model of mild traumatic brain injury.Frontiers in molecular neuroscience · 2022Article
- Resting-State Functional Magnetic Resonance Imaging of Interhemispheric Functional Connectivity in Experimental Traumatic Brain Injury.Neurotrauma reports · 2021Article
- Brain-Immune Interactions and Neuroinflammation After Traumatic Brain Injury.Frontiers in neuroscience · 2019Review
- Acetazolamide Treatment Prevents Redistribution of Astrocyte Aquaporin 4 after Murine Traumatic Brain Injury.Neuroscience journal · 2019Article
- Hyperthermia and Mild Traumatic Brain Injury: Effects on Inflammation and the Cerebral Vasculature.Journal of neurotrauma · 2018Article
- Chronic global analysis of vascular permeability and cerebral blood flow after bone marrow stromal cell treatment of traumatic brain injury in the rat: A long-term MRI study.Brain research · 2017Article
- Using functional and molecular MRI techniques to detect neuroinflammation and neuroprotection after traumatic brain injury.Brain, behavior, and immunity · 2017Article
- White matter changes in patients with mild traumatic brain injury: MRI perspective.Concussion (London, England) · 2017Review
- Intraarterial transplantation of human umbilical cord blood mononuclear cells in hyperacute stroke improves vascular function.Stem cell research & therapy · 2017Article
- Stimulating mitochondria to protect the brain following traumatic brain injury.Neural regeneration research · 2016Article
- Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.Advanced materials (Deerfield Beach, Fla.) · 2016Article
- Chronic cerebrovascular dysfunction after traumatic brain injury.Journal of neuroscience research · 2016Review
- Magnetic Resonance Imaging of Cerebral Blood Flow in Animal Stroke Models.Brain circulation · 2016Article
- A brief report on MRI investigation of experimental traumatic brain injury.Neural regeneration research · 2016Article
- Ultrasound, photoacoustic, and magnetic resonance imaging to study hyperacute pathophysiology of traumatic and vascular brain injury.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
This study investigated the effects of perturbed cerebral blood flow (CBF) and cerebrovascular reactivity (CR) on relaxation time constant (T2), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and behavioral scores at 1 and 3 hours, 2, 7, and 14 days after traumatic brain injury (TBI) in rats. Open-skull TBI was induced over the left primary forelimb somatosensory cortex (N=8 and 3 sham). We found the abnormal areas of CBF and CR on days 0 and 2 were larger than those of the T2, ADC, and FA abnormalities. In the impact core, CBF was reduced on day 0, increased to 2.5 times of normal on day 2, and returned toward normal by day 14, whereas in the tissue surrounding the impact, hypoperfusion was observed on days 0 and 2. CR in the impact core was negative, most severe on day 2 but gradually returned toward normal. T2, ADC, and FA abnormalities in the impact core were detected on day 0, peaked on day 2, and pseudonormalized by day 14. Lesion volumes peaked on day 2 and were temporally correlated with forelimb asymmetry and foot-fault scores. This study quantified the effects of perturbed CBF and CR on structural magnetic resonance imaging and behavioral readouts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.