ReviewProtein science : a publication of the Protein Society2015
Structure-function correlations in tyrosinases.
Review in Protein science : a publication of the Protein Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed, 219 citations in OpenAlex.
- Rational design of triazole tyrosinase inhibitors via integrated free energy calculations.Molecular diversity · 2026Article
- A binuclear copper enzyme platform for enantioconvergent radical (pseudo)halogenation.bioRxiv : the preprint server for biology · 2026Article
- Integrated Phytochemical Profiling, In Vitro Bioactivity, Molecular Docking, and Pharmacokinetic-Toxicity Evaluation ofLife (Basel, Switzerland) · 2026Article
- Broad pH-resistant microdroplet SERS platform based on Ag@SiOMicrosystems & nanoengineering · 2026Article
- Enhancing Enzymatic Bioconjugation Efficiency via Computer-Based Installation of a Substrate Recruitment Domain.Bioconjugate chemistry · 2026Article
- Neuroprotective and Renoprotective Potential of a Hydroethanolic Extract From the Aerial Parts of Mattiastrum paphlagonicum Bornm. (Boraginaceae).Chemistry & biodiversity · 2026Article
- Tyrosinase Cross-Linked PEG Hydrogels with DAT and DATT as Artificial Substrates: Design, Structure, and Functions.Biomacromolecules · 2026Article
- Purification and activity enhancement of extracellular tyrosinase from a protease-silenced zygomycete Amylomyces rouxii strain.Folia microbiologica · 2026Article
- Article
- Discovery of Furan-tethered Triazolothiadiazoles and Triazolothiadiazines as Potent Tyrosinase Inhibitors for the Treatment of Skin Diseases: Insights from Kinetics Data and Computational Modeling.Current medicinal chemistry · 2026Article
- Theoretical studies of arbutin, glutathione, and sea cucumber extracts as inhibitors of tyrosinase.Scientific reports · 2025Article
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- Article
- Structure-based design and evaluation of tyrosinase inhibitors targeting both human and mushroom isozymes.RSC medicinal chemistry · 2025Article
- Inhibition of Tyrosinase and Melanogenesis by a White Mulberry Fruit Extract.International journal of molecular sciences · 2025Article
- BioBrigit, a Hybrid Machine Learning and Knowledge-Based Approach to Model Metal Pathways in Proteins: Application to a Dicopper Tyrosinase.ACS omega · 2025Article
- Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome.Chemical reviews · 2025Review
- 5,7-Dihydroxy-4-Methylcoumarin as a Functional Compound for Skin Pigmentation and Human Skin Safety.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types.iScience · 2025Article
- Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of (Molecules (Basel, Switzerland) · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tyrosinases are metalloenzymes belonging to the type-3 copper protein family which contain two copper ions in the active site. They are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. Two other members of this family are catechol oxidases, which are prevalent mainly in plants and perform only the second oxidation step, and hemocyanins, which lack enzymatic activity and are oxygen carriers. In the last decade, several structures of plant and bacterial tyrosinases were determined, some with substrates or inhibitors, highlighting features and residues which are important for copper uptake and catalysis. This review summarizes the updated information on structure-function correlations in tyrosinases along with comparison to other type-3 copper proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.