ArticleNature communications2015
Enantiomer-specific analysis of multi-component mixtures by correlated electron imaging-ion mass spectrometry.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 83 citations in OpenAlex.
- Spectroscopy and Conformer-Selective Photoelectron Circular Dichroism of Chiral Molecules.Chemistry, an Asian journal · 2026Review
- All-optically tunable electromagnetic chirality transfer.Science advances · 2026Article
- Enantiospecific two-photon electric-dipole selection rule of chiral molecules.Science advances · 2025Article
- High-performance gas-phase chiral enantiomer detectors based on chiral-induced spin selectivity effect.Nature communications · 2025Article
- Determination of the Molar Fraction and Enantiomeric Excess of Electrosprayed Amino Acid Anions Employing Photoelectron Circular Dichroism.Analytical chemistry · 2025Article
- Photoelectron Circular Dichroism in the Photodetachment of Deprotonated 1-Phenylethanol.The journal of physical chemistry letters · 2025Article
- Identification of the enantiomeric nature of 2-keto-3-deoxy-galactonate in the catabolic pathway of 3,6-anhydro-L-galactose.Applied microbiology and biotechnology · 2023Article
- Induced photoelectron circular dichroism onto an achiral chromophore.Nature communications · 2023Article
- Fast and precise chiroptical spectroscopy by photoelectron elliptical dichroism.Physical chemistry chemical physics : PCCP · 2023Article
- Imaging Photoelectron Circular Dichroism in the Detachment of Mass-Selected Chiral Anions.Angewandte Chemie (International ed. in English) · 2023Article
- Ultrafast chirality: the road to efficient chiral measurements.Physical chemistry chemical physics : PCCP · 2022Review
- Photoionization of the aqueous phase: clusters, droplets and liquid jets.Physical chemistry chemical physics : PCCP · 2022Review
- Assignment-free chirality detection in unknown samples via microwave three-wave mixing.Communications chemistry · 2022Article
- Conformer-dependent vacuum ultraviolet photodynamics and chiral asymmetries in pure enantiomers of gas phase proline.Communications chemistry · 2021Article
- Chiral discrimination by recollision enhanced femtosecond laser mass spectrometry.Scientific reports · 2020Article
- Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism.Nature communications · 2018Article
- An imaging photoelectron-photoion coincidence investigation of homochiral 2R,3R-butanediol clusters.The Journal of chemical physics · 2017Article
- Chromatographic Separation of Vitamin E Enantiomers.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Simultaneous, enantiomer-specific identification of chiral molecules in multi-component mixtures is extremely challenging. Many established techniques for single-component analysis fail to provide selectivity in multi-component mixtures and lack sensitivity for dilute samples. Here we show how enantiomers may be differentiated by mass-selected photoelectron circular dichroism using an electron-ion coincidence imaging spectrometer. As proof of concept, vapours containing ∼1% of two chiral monoterpene molecules, limonene and camphor, are irradiated by a circularly polarized femtosecond laser, resulting in multiphoton near-threshold ionization with little molecular fragmentation. Large chiral asymmetries (2-4%) are observed in the mass-tagged photoelectron angular distributions. These asymmetries switch sign according to the handedness (R- or S-) of the enantiomer in the mixture and scale with enantiomeric excess of a component. The results demonstrate that mass spectrometric identification of mixtures of chiral molecules and quantitative determination of enantiomeric excess can be achieved in a table-top instrument.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.