Evidence map›Paper›PMID 26104013›Full record

Trial reportAlimentary pharmacology & therapeutics2015

Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome.

B P Chumpitazi, J L Cope, E B Hollister, C M Tsai, A R McMeans, R A Luna, J Versalovic, R J Shulman

4 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alimentary pharmacology & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 170 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 9 pooled it
29.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01339117 nacompletednot on this map

Delivered Dietary Intervention for Children With Irritable Bowel Syndrome

TypeinterventionalSponsorBaylor College of MedicineRan2011 to 2017Enrolled40ConditionsIrritable Bowel Syndrome, Abdominal PainArmsLow fermentable substrate diet, High fermentable substrate diet
NCT02565355 nacompletednot on this map

Randomized Controlled Trial of Food Elimination Based on IgG Antibodies for Treatment of Functional Gastrointestinal Diseases (FGIDs) in Children

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2015 to 2017Enrolled60ConditionsFunctional Gastrointestinal Disorders, Functional Abdominal Pain Syndrome, Abdominal Pain (AP)ArmsDietary Exclusion, Standard Treatment
NCT02902926 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Comparison of Microbiota and Quality of Life for a Low FODMAPs Versus Standard Dietary Advice in Patients With Irritable Bowel Syndrome

TypeinterventionalSponsorJinsong WangRan2016 to 2017Enrolled120ConditionsFood HabitsArmsLow FODMAPs Diet, Diet instruction
NCT06268964 phase1 / phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Comparative Effect of Trimebutine and Probiotics on Functional Abdominal Pain Disorders (FAPD) in Children: Randomized Clinical Trial (RCT)

TypeinterventionalSponsorUniversidad de ColimaRan2024 to 2025Enrolled82ConditionsFunctional Abdominal Pain Syndrome, Functional Gastrointestinal Disorders, Irritable Bowel Syndrome Variant of ChildhoodArmsTrimebutine, Lactobacillus rhamnosus, Placebo
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 9 syntheses or guidelines pooled it, 420 citations in OpenAlex.

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  9. Dietary interventions for recurrent abdominal pain in childhood.The Cochrane database of systematic reviews · 2017
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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

B P ChumpitaziDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
J L CopeDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
E B HollisterDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
C M TsaiDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
A R McMeansChildren's Nutrition Research Center, Houston, TX, USA.
R A LunaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
J VersalovicDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
R J ShulmanDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · USTexas Children's Hospital · USChildren's Nutrition Research Center at Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Recurrent Abdominal Pain in ChildrenR01NR005337 · NINR · BAYLOR COLLEGE OF MEDICINE · PI SHULMAN, ROBERT J · 2002 to 2012
$4.3M
The Human Microbiome in Pediatric Abdominal Pain and Intestinal InflammationUH3DK083990 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2010 to 2012
$3.3M
Intestinal Microbiome Fructan Metabolism and Symptom Generation in Childhood IBSK23DK101688 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHUMPITAZI, BRUNO PEDRO · 2014 to 2018
$879k
NIDDK NIH HHS K23 DK101688NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30 DK56338NIDDK NIH HHS UH3 DK083990NINR NIH HHS R01 NR005337NINR NIH HHS R01 NR05337
6 · The paper itself

Abstract

backgroundA low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h.

aimTo determine the efficacy of a low FODMAP diet in childhood IBS and whether gut microbial composition and/or metabolic capacity are associated with its efficacy.

methodsIn a double-blind, crossover trial, children with Rome III IBS completed a 1-week baseline period. They then were randomised to a low FODMAP diet or typical American childhood diet (TACD), followed by a 5-day washout period before crossing over to the other diet. GI symptoms were assessed with abdominal pain frequency being the primary outcome. Baseline gut microbial composition (16S rRNA sequencing) and metabolic capacity (PICRUSt) were determined. Metagenomic biomarker discovery (LEfSe) compared Responders (≥50% decrease in abdominal pain frequency on low FODMAP diet only) vs. Nonresponders (no improvement during either intervention).

resultsThirty-three children completed the study. Less abdominal pain occurred during the low FODMAP diet vs. TACD [1.1 ± 0.2 (SEM) episodes/day vs. 1.7 ± 0.4, P < 0.05]. Compared to baseline (1.4 ± 0.2), children had fewer daily abdominal pain episodes during the low FODMAP diet (P < 0.01) but more episodes during the TACD (P < 0.01). Responders were enriched at baseline in taxa with known greater saccharolytic metabolic capacity (e.g. Bacteroides, Ruminococcaceae, Faecalibacterium prausnitzii) and three Kyoto Encyclopedia of Genes and Genomes orthologues, of which two relate to carbohydrate metabolism.

conclusionsIn childhood IBS, a low FODMAP diet decreases abdominal pain frequency. Gut microbiome biomarkers may be associated with low FODMAP diet efficacy. ClinicalTrials.gov identifier: NCT01339117.

Indexed as

Gastrointestinal MicrobiomeAbdominal PainAdolescentBiomarkersChildCross-Over StudiesDisaccharidesDouble-Blind MethodFemaleFermentationHumansIrritable Bowel SyndromeMaleMonosaccharidesOligosaccharidesPolymersBiomarkersDisaccharidesMonosaccharidesOligosaccharidesPolymerspolyolRNA, Ribosomal, 16S

Identifiers

PMID26104013
PMCPMC4514898
OpenAlexW1709638636

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.