Evidence map›Paper›PMID 26103984›Full record

ReviewCirculation journal : official journal of the Japanese Circulation Society2015

Natriuretic Peptides and Cardiometabolic Health.

Deepak K Gupta, Thomas J Wang

Open access · diamondAbstract readReview
In one paragraph

Review in Circulation journal : official journal of the Japanese Circulation Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 94 citations in OpenAlex.

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  20. Network meta-analysis of sacubitril/valsartan for the treatment of essential hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Deepak K GuptaVanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine.
Thomas J Wang
Cardiovascular Research Center · BRVanderbilt University · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7M
Obesity, salt-sensitivity, and the natriuretic peptidesR01HL102780 · NHLBI · VANDERBILT UNIVERSITY · PI WANG, THOMAS J. · 2011 to 2014
$1.7M
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NHLBI NIH HHS K12 HL109019NHLBI NIH HHS R01 HL102780NHLBI NIH HHS R01-HL-102780
6 · The paper itself

Abstract

Natriuretic peptides are cardiac-derived hormones with a range of protective functions, including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved insulin sensitivity. Their actions are mediated through membrane-bound guanylyl cyclases that lead to production of the intracellular second-messenger cyclic guanosine monophosphate. A growing body of evidence demonstrates that genetic and acquired deficiencies of the natriuretic peptide system can promote hypertension, cardiac hypertrophy, obesity, diabetes mellitus, the metabolic syndrome, and heart failure. Clinically, natriuretic peptides are robust diagnostic and prognostic markers, and augmenting natriuretic peptides is a target for therapeutic strategies in cardiometabolic disease. This review will summarize current understanding and highlight novel aspects of natriuretic peptide biology.

Indexed as

Second Messenger SystemsBiomarkersCardiovascular DiseasesCyclic GMPHumansMetabolic DiseasesNatriuretic PeptidesBiomarkersCyclic GMPNatriuretic Peptides

Identifiers

PMID26103984
PMCPMC4893202
OpenAlexW1599861535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.