ArticleHeredity2015
Genetic and phenotypic influences on copulatory plug survival in mice.
Article in Heredity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Genetic disruption of the baculum compromises the ability of male mice to copulate.PLoS genetics · 2025Article
- Pathologic copulatory lock in a genetically engineered laboratory mouse breeding pair.Laboratory animals · 2023Article
- Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice.Pharmaceutical biology · 2022Article
- Male-derived copulatory plugs enhance implantation success in female Mus musculus.Biology of reproduction · 2021Article
- Seminal fluid and accessory male investment in sperm competition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Revealing mechanisms of mating plug function under sexual selection.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genetic and environmental variation in transcriptional expression of seminal fluid proteins.Heredity · 2019Article
- Structural complexity and molecular heterogeneity of a butterfly ejaculate reflect a complex history of selection.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Copulatory plugs inhibit the reproductive success of rival males.Journal of evolutionary biology · 2016Article
- Sperm competition risk drives plasticity in seminal fluid composition.BMC biology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Across a diversity of animals, male seminal fluid coagulates upon ejaculation to form a hardened structure known as a copulatory plug. Previous studies suggest that copulatory plugs evolved as a mechanism for males to impede remating by females, but detailed investigations into the time course over which plugs survive in the female's reproductive tract are lacking. Here, we cross males from eight inbred strains to females from two inbred strains of house mice (Mus musculus domesticus). Plug survival was significantly affected by male genotype. Against intuition, plug survival time was negatively correlated with plug size: long-lasting plugs were small and relatively more susceptible to proteolysis. Plug size was associated with divergence in major protein composition of seminal vesicle fluid, suggesting that changes in gene expression may play an important role in plug dynamics. In contrast, we found no correlation to genetic variation in the protein-coding regions of five genes thought to be important in copulatory plug formation (Tgm4, Svs1, Svs2, Svs4 and Svs5). Our study demonstrates a complex relationship between copulatory plug characteristics and survival. We discuss several models to explain unexpected variation in plug phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.