ArticleBritish journal of cancer2015
MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project.
Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 60 citations in OpenAlex.
- Predictors of correct recall of genetic risk information among Hispanic individuals in Florida and Puerto Rico.Patient education and counseling · 2023Trial
- Assessment of skin cancer precision prevention materials among Hispanics in Florida and Puerto Rico.Patient education and counseling · 2022Trial
- A randomized clinical trial of precision prevention materials incorporatingCancer research communications · 2022Trial
- A hybrid effectiveness-implementation trial to integrate precision skin cancer risk feedback in federally qualified health centers.Contemporary clinical trials · 2026Article
- Risk factors for the development of acral melanoma: A multi-institutional, retrospective cohort study.JAAD international · 2026Article
- Novel MC1R variants cause red hair and lighter skin color.HGG advances · 2026Article
- Genetic Landscape of Familial Melanoma.Genes · 2025Review
- Assessing MC1R Variants in Lentigo Maligna Melanoma within the Utah Population.Cancer research communications · 2025Article
- Assessment of the Influence of UVR in Cutaneous Melanoma.Photodermatology, photoimmunology & photomedicine · 2025Review
- Gray Hair: From Preventive to Treatment.Clinical, cosmetic and investigational dermatology · 2025Review
- The Risk Information and Skin-cancer Education for Undergraduate Prevention (RISE-UP) Study: Protocol for a Trial of Personalized Sun Protection Interventions for Skin Cancer Prevention among Undergraduate Students.Contemporary clinical trials · 2024Article
- Article
- Melanocortin-1 Receptor Expression as a Marker of Progression in Melanoma.JCO precision oncology · 2024Article
- Risk Factors and Innovations in Risk Assessment for Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma.Cancers · 2024Review
- Immunotherapy and Its Timing in Advanced Basal Cell Carcinoma Treatment.Dermatology practical & conceptual · 2023Review
- Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma.Journal of translational medicine · 2023Review
- Phenotypic and Dermoscopic Patterns of Familial Melanocytic Lesions: A Pilot Study in a Third-Level Center.Cancers · 2023Article
- Qualitative assessment of uptake retention and evaluation of prevention materials for skin cancer among Hispanics.Patient education and counseling · 2023Article
- The αMSH-Dependent PI3K Pathway Supports Energy Metabolism, via Glucose Uptake, in Melanoma Cells.Cells · 2023Article
- AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis.Cancer research · 2023Article
Corrections and comments
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Authors and funding
24 authors at 14 institutions in 11 countries.
Funding
Abstract
backgroundThe melanocortin-1-receptor (MC1R) gene regulates human pigmentation and is highly polymorphic in populations of European origins. The aims of this study were to evaluate the association between MC1R variants and the risk of non-melanoma skin cancer (NMSC), and to investigate whether risk estimates differed by phenotypic characteristics.
methodsData on 3527 NMSC cases and 9391 controls were gathered through the M-SKIP Project, an international pooled-analysis on MC1R, skin cancer and phenotypic characteristics. We calculated summary odds ratios (SOR) with random-effect models, and performed stratified analyses.
resultsSubjects carrying at least one MC1R variant had an increased risk of NMSC overall, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC): SOR (95%CI) were 1.48 (1.24-1.76), 1.39 (1.15-1.69) and 1.61 (1.35-1.91), respectively. All of the investigated variants showed positive associations with NMSC, with consistent significant results obtained for V60L, D84E, V92M, R151C, R160W, R163Q and D294H: SOR (95%CI) ranged from 1.42 (1.19-1.70) for V60L to 2.66 (1.06-6.65) for D84E variant. In stratified analysis, there was no consistent pattern of association between MC1R and NMSC by skin type, but we consistently observed higher SORs for subjects without red hair.
conclusionsOur pooled-analysis highlighted a role of MC1R variants in NMSC development and suggested an effect modification by red hair colour phenotype.
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