ArticleJournal of applied clinical medical physics2015
Is there a preferred IMRT technique for left-breast irradiation?
Article in Journal of applied clinical medical physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The use of Hybrid Techniques in Whole-Breast Radiotherapy: A Systematic Review.Technology in cancer research & treatmentPooled it
- Dosimetric and radiobiological evaluations as well as technical aspects of left breast treatment employing DIBH with SGRT in radiotherapy with IMRT step and shoot, IMRT Dynamic MLC and VMAT.Journal of applied clinical medical physics · 2026Article
- Impact of excluding internal mammary node coverage on musculoskeletal dosimetry in breast radiotherapy.Clinical and translational radiation oncology · 2026Article
- Clinical Implementation of Cone Beam Computed Tomography-Guided Online Adaptive Radiation Therapy in Whole Breast Irradiation.Advances in radiation oncology · 2025Article
- Master Breast Radiation Planning: Simple Guide for Radiation Oncology Residents.Advances in radiation oncology · 2024Review
- Radiation Dose to Critical Cardiac Structures from Three-Dimensional Conformal Radiation Therapy (3D-CRT), Intensity-Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) Techniques for Left-Sided Breast Cancer.Journal of personalized medicine · 2024Article
- Improved treatment robustness of postoperative breast cancer radiotherapy including supraclavicular nodes.Physics and imaging in radiation oncology · 2022Article
- Response to Letter to the Editor.Technical innovations & patient support in radiation oncology · 2021Article
- Split-VMAT technique to control the deep inspiration breath hold time for breast cancer radiotherapy.Radiation oncology (London, England) · 2021Article
- Beam complexity and monitor unit efficiency comparison in two different volumetric modulated arc therapy delivery systems using automated planning.BMC cancer · 2021Article
- Article
- Single click automated breast planning with iterative optimization.Journal of applied clinical medical physics · 2020Article
- Hybrid volumetric-modulated arc therapy for postoperative breast cancer including regional lymph nodes: the advantage of dosimetric data and safety of toxicities.Journal of radiation research · 2020Article
- Hybrid planning techniques for hypofractionated whole-breast irradiation using flattening filter-free beams.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020Article
- Fixed-jaw technique to improve IMRT plan quality for the treatment of cervical and upper thoracic esophageal cancer.Journal of applied clinical medical physics · 2019Article
- Hybrid volumetric modulated arc therapy for whole breast irradiation: a dosimetric comparison of different arc designs.La Radiologia medica · 2019Article
- Dosimetric comparison of VMAT with integrated skin flash to 3D field-in-field tangents for left breast irradiation.Journal of applied clinical medical physics · 2019Article
- Tangent-based volumetric modulated arc therapy for advanced left breast cancer.Radiation oncology (London, England) · 2018Article
- Dosimetric analysis of tangent-based volumetric modulated arc therapy with deep inspiration breath-hold technique for left breast cancer patients.Radiation oncology (London, England) · 2018Article
- Dosimetric evaluation and systematic review of radiation therapy techniques for early stage node-negative breast cancer treatment.Cancer management and research · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Not all clinics have breath-hold radiotherapy available for left-breast irradiation. However intensity-modulated radiotherapy (IMRT) has also been advocated as a means of lowering heart doses. There is currently no large-scale, long-term follow-up data after breast IMRT and, since dose distributions may differ from classic tangent-based radiotherapy, caution is needed to avoid unexpected worsening of the late toxicity profile. We compared four IMRT techniques for free-breathing left-breast irradiation. Consistent with the aforementioned concerns, our goal in planning was to prioritize organ at risk (OAR) sparing in a way that mimicked tangent-based radiotherapy. Ten simultaneous integrated boost treatment plans (PTVelective = 15 × 2.67 Gy; PTVboost = 15 × 3.35 Gy) were created using 1) hybrid-IMRT (H-IMRT), 2) full IMRT (F-IMRT), and 3) volumetric-modulated arc therapy with two partial arcs (2ARC) and 4) six partial arcs (6ARC). Reduction in OAR mean and low dose was prioritized. End-points included OAR sparing (e.g., heart, left anterior descending artery [LAD+3 mm], lungs, and contralateral breast) and PTV coverage/dose homogeneity. Under these conditions we found the following: 1) H-IMRT provided the best mean and low dose OAR sparing, PTVelective coverage (mean V95% = 98%), PTVboost coverage (V95% = 98%), and PTV homogeneity. However, it delivered most intermediate-high dose to the heart, LAD+3 mm and ipsilateral lung; 2) 6ARC had the best intermediate-high dose sparing, followed by F-IMRT, but this was at the expense of more dose in the contralateral lung and breast and worse PTV coverage (PTVelective mean V95% = 96%/97% and PTVboost mean V95% = 91%/96% for 6ARC/F-IMRT). When trying to spare mean and low dose to OARs, the preferred IMRT technique for left-breast irradiation without breath-hold was H-IMRT. This is currently the standard solution in our institution for left-breast radiotherapy under free-breathing and breath-hold conditions.
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