Evidence map›Paper›PMID 26102615›Full record

ReviewTransplantation2015

The Evolving Roles of Memory Immune Cells in Transplantation.

Wenhao Chen, Rafik M Ghobrial, Xian C Li

Abstract readReview
In one paragraph

Review in Transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2020
    Article
  5. Article
  6. Review
  7. Ablation of interferon regulatory factor 4 in T cells induces "memory" of transplant tolerance that is irreversible by immune checkpoint blockade.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  8. Belatacept-Resistant Rejection Is Associated With CD28American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wenhao Chen1 Department of Surgery, Houston Methodist Hospital and Center for Immunobiology and Transplant Research, Houston Methodist Research Institute, Texas Medical Center, Houston, TX.
Rafik M Ghobrial
Xian C Li
Houston Methodist · US

Funding

Modulation of innate immune cells to create transplant toleranceR01AI080779 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Xian Chang Li · 2011 to 2026
$5.2M
Control of Treg exhaustion by OX40R01AI106200 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LI, XIAN CHANG · 2014 to 2025
$4.2M
Mechanisms mediating CD28 &CD154 independent rejectionR01AI057409 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LI, XIAN CHANG · 2004 to 2010
$1.8M
Mechanisms of OX40 in peripheral transplant toleranceR01AI070315 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LI, XIAN CHANG · 2007 to 2011
$1.7M
NIAID NIH HHS R01 AI057409NIAID NIH HHS R01 AI070315NIAID NIH HHS R01 AI080779NIAID NIH HHS R01 AI106200
6 · The paper itself

Abstract

Memory cells are the products of immune responses but also exert significant impact on subsequent immunity and immune tolerance, thus placing them in a unique position in transplant research. Memory cells are heterogeneous, including not only memory T cells but also memory B cells and innate memory cells. Memory cells are a critical component of protective immunity against invading pathogens, especially in immunosuppressed patients, but they also mediate graft loss and tolerance resistance. Recent studies suggest that some memory cells unexpectedly act as regulatory cells, promoting rather than hindering transplant survival. This functional diversity makes therapeutic targeting of memory cells a challenging task in transplantation. In this article, we highlight recent advances in our understanding of memory cells, focusing on diversity of memory cells and mechanisms involved in their induction and functions. We also provide a broad overview on the challenges and opportunities in targeting memory cells in the induction of transplant tolerance.

Indexed as

Immunologic MemoryAnimalsB-LymphocytesCell LineageHomeostasisHumansImmunosuppression TherapyImmunosuppressive AgentsMice, TransgenicT-LymphocytesTransplantationTransplantation ImmunologyTransplantation ToleranceImmunosuppressive Agents

Identifiers

PMID26102615
PMCPMC4591096
OpenAlexW2267027686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.