ArticleBioconjugate chemistry2015
Nanostar Clustering Improves the Sensitivity of Plasmonic Assays.
Article in Bioconjugate chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Review
- Magnetic Gold Nanoparticles with Idealized Coating for Enhanced Point-Of-Care Sensing.Advanced healthcare materials · 2022Article
- Novel Nanoplasmonic-Structure-Based Integrated Microfluidic Biosensors for Label-Free in Situ Immune Functional Analysis: A review of recent progress.IEEE nanotechnology magazine · 2020Article
- Plasmonic Detection of Glucose in Serum Based on Biocatalytic Shape-Altering of Gold Nanostars.Biosensors · 2019Article
- Intelligent Photosensitive Mesenchymal Stem Cells and Cell-Derived Microvesicles for Photothermal Therapy of Prostate Cancer.Nanotheranostics · 2019Article
- Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing.Bioconjugate chemistry · 2017Article
- Digital diffraction detection of protein markers for avian influenza.Lab on a chip · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Star-shaped Au nanoparticles (Au nanostars, AuNS) have been developed to improve the plasmonic sensitivity, but their application has largely been limited to single-particle probes. We herein describe a AuNS clustering assay based on nanoscale self-assembly of multiple AuNS and which further increases detection sensitivity. We show that each cluster contains multiple nanogaps to concentrate electric fields, thereby amplifying the signal via plasmon coupling. Numerical simulation indicated that AuNS clusters assume up to 460-fold higher field density than Au nanosphere clusters of similar mass. The results were validated in model assays of protein biomarker detection. The AuNS clustering assay showed higher sensitivity than Au nanosphere. Minimizing the size of affinity ligand was found important to tightly confine electric fields and improve the sensitivity. The resulting assay is simple and fast and can be readily applied to point-of-care molecular detection schemes.
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Registered trials
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