ReviewCurrent opinion in microbiology2015
Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes.
Review in Current opinion in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- The LEF1-LAG3 axis regulates CD4Parasites & vectors · 2026Article
- Liver-stage fate determination inFrontiers in microbiology · 2022Article
- Review
- Characterization of the Tubovesicular Network inFrontiers in cellular and infection microbiology · 2021Article
- The Selection of a Hepatocyte Cell Line Susceptible toFrontiers in microbiology · 2019Article
- Next Generation Histology-Directed Imaging Mass Spectrometry Driven by Autofluorescence Microscopy.Analytical chemistry · 2018Article
- A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages.Malaria journal · 2018Article
- A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.Nature communications · 2018Article
- Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity.Frontiers in immunology · 2018Review
- The Promise of Systems Biology Approaches for Revealing Host Pathogen Interactions in Malaria.Frontiers in microbiology · 2017Review
- An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials.Future microbiology · 2016Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Plasmodium parasites belong to the Apicomplexan phylum, which consists mostly of obligate intracellular pathogens that vary dramatically in host cell tropism. Plasmodium sporozoites are highly hepatophilic. The specific molecular mechanisms, which facilitate sporozoite selection and successful infection of hepatocytes, remain poorly defined. Here, we discuss the parasite and host factors which are critical to hepatocyte infection. We derive a model where sporozoites initially select host cells that constitute a permissive environment and then further refine the chosen hepatocyte during liver stage development, ensuring life cycle progression. While many unknowns of pre-erythrocytic infection remain, advancing models and technologies that enable analysis of human malaria parasites and of single infected cells will catalyze a comprehensive understanding of the interaction between the malaria parasite and its hepatocyte host.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.