ArticleThe journal of pain2015
Pain Among High-Risk Patients on Methadone Maintenance Treatment.
Article in The journal of pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- A pilot study assessing acceptability and feasibility of hatha yoga for chronic pain in people receiving opioid agonist therapy for opioid use disorder.Journal of substance abuse treatment · 2019Trial
- Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial).PloS one · 2017Trial
- Associations Between Pain Severity and Opioid Agonist Treatment Among People With Drug Injection Experience in Australia.Drug and alcohol review · 2026Article
- Trait impulsivity prospectively predicts lower methadone treatment retention: moderation by pain catastrophizing.Addiction science & clinical practice · 2026Observational
- Machine learning model for predicting hepatitis C seroconversion in methadone maintenance patients in China.BMJ public health · 2025Article
- Evaluation of intervention components to maximize yoga practice among people with chronic pain taking opioid agonist therapy: A factorial experiment using the multiphase optimization strategy framework.Contemporary clinical trials · 2024Article
- Mental and physical health characteristics of older and younger adults receiving medication for opioid use disorder.Frontiers in public health · 2024Article
- Nociceptive Flexion Reflex Threshold is No Suitable Marker for Diagnosing Opioid-Induced Hyperalgesia.Journal of pain research · 2024Article
- Weight change among patients engaged in medication treatment for opioid use disorder: a scoping review.The American journal of drug and alcohol abuse · 2023Article
- The impact of body image dissatisfaction on psychological distress and health-related quality of life among patients in methadone treatment.The American journal on addictions · 2023Article
- Profiles of Patients with Opioid Use Disorders Presenting a History of Suicidal Ideations and Attempts.The Psychiatric quarterly · 2022Article
- Opioid dependence disorder and comorbid chronic pain: comparison of groups based on patient-attributed direction of the causal relationship between the two conditions.British journal of pain · 2022Article
- Association between recent overdose and chronic pain among individuals in treatment for opioid use disorder.PloS one · 2022Article
- Problematic Opioid Use: A Scoping Literature Review of Profiles.Substance abuse : research and treatment · 2022Article
- Craving mediates the association between momentary pain and illicit opioid use during treatment for opioid-use disorder: an ecological momentary assessment study.Addiction (Abingdon, England) · 2021Observational
- Perceived social support in patients with chronic pain with and without opioid use disorder and role of medication for opioid use disorder.Drug and alcohol dependence · 2021Article
- "It's Helped Me a Lot, Just Like to Stay Alive": a Qualitative Analysis of Outcomes of a Novel Hydromorphone Tablet Distribution Program in Vancouver, Canada.Journal of urban health : bulletin of the New York Academy of Medicine · 2021Article
- Prevalence and Characteristics of Chronic Pain in Buprenorphine and Methadone-Maintained Patients.Frontiers in psychiatry · 2021Article
- Motivations to initiate injectable hydromorphone and diacetylmorphine treatment: A qualitative study of patient experiences in Vancouver, Canada.The International journal on drug policy · 2020Article
- Greater Pain Severity is Associated with Inability to Access Addiction Treatment Among a Cohort of People Who Use Drugs.Journal of pain research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The complexity of treating concurrent pain and opioid dependence among many methadone-maintained individuals presents a major challenge in many clinical settings. Furthermore, recent expert guidelines have called for increased research on the safety of methadone in the context of chronic pain. This study explores the prevalence and correlates of pain among a prospective cohort of people who use illicit drugs in Vancouver, British Columbia, Canada, who reported enrollment in methadone maintenance treatment (MMT) between 2011 and 2014. Among the 823 participants eligible for this analysis, 338 (40.9%) reported moderate pain and 91 (11.1%) reported extreme pain at the first study visit. In multivariable, generalized, linear mixed model analyses, higher pain severity was positively and independently associated with self-managing pain (adjusted odds ratio [AOR] 2.15, 95% confidence interval [CI] 1.77-2.60), patient perception of methadone dose being too low (AOR 1.82, 95% CI 1.41-2.34), older age (AOR 1.31, 95% CI 1.13-1.51), having a physical disability (AOR 4.59, 95% CI 3.73-5.64), having ever been diagnosed with a mental illness (AOR 1.44, 95% CI 1.13-1.84), white ethnicity (AOR 1.42, 95% CI 1.10-1.83), and marijuana use (AOR 1.25, 95% CI 1.02-1.52). These findings suggest several areas for clinical intervention, particularly related to patient education and alternative analgesic approaches for MMT patients experiencing pain. Perspective: To better understand the complexity of concurrent pain and opioid dependency among individuals on methadone maintenance treatment, this article describes the prevalence and correlates of higher pain severity among methadone-maintained people who use illicit drugs. Patients on methadone with comorbid pain may benefit from education and alternative analgesic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.