ArticleAvicenna journal of phytomedicine
The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Acute Intake of Fructose Increases Arterial Pressure in Humans: A Meta-Analysis and Systematic Review.Nutrients · 2024Pooled it
- Safety evaluation and biochemical efficacy of celery seed extract (Apium Graveolens) capsules in hypertensive patients: a randomized, triple-blind, placebo-controlled, cross-over, clinical trial.Inflammopharmacology · 2022Trial
- Article
- Antihypertensive Property of Celery: A Narrative Review on Current Knowledge.International journal of food science · 2024Review
- The effect of celery (Food science & nutrition · 2023Article
- Root Vegetables-Composition, Health Effects, and Contaminants.International journal of environmental research and public health · 2022Review
- Loci underlying leaf agronomic traits identified by re-sequencing celery accessions based on an assembled genome.iScience · 2022Article
- Influence of the meteorological conditions and some pollutants on PMJournal of environmental health science & engineering · 2021Article
- Blood Pressure Change After Celery Juice Ingestion in a Hypertensive Elderly Male.Journal of chiropractic medicine · 2021Article
- Ellagic Acid Protects Cardiac Arrhythmias Following Global Cerebral Ischemia/Reperfusion Model.Galen medical journal · 2019Article
- Article
- Article
- Chronotropic, Inotropic and Dromotropic Parameters of the Heart and Oxidative Stress in Rats Receiving High Doses of Fructose.Galen medical journal · 2019Article
- Article
- Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels.Molecules (Basel, Switzerland) · 2018Article
- Article
- CeleryDB: a genomic database for celery.Database : the journal of biological databases and curation · 2018Article
- Review
- Transcriptional profiling of genes involved in ascorbic acid biosynthesis, recycling, and degradation during three leaf developmental stages in celery.Molecular genetics and genomics : MGG · 2016Article
- The effects of PM10 on electrocardiogram parameters, blood pressure and oxidative stress in healthy rats: the protective effects of vanillic acid.Environmental science and pollution research international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHypertension is one of the most common diseases of the modern era. This study evaluates the effect of hydro-alcoholic celery leaf extract onsystolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose. MATERIALS AND
methodsSprague Dawley rats were divided into five groups: 1) control group (free access to tap drinking water), 2) group receiving 200mg/kg celery leaf extract, 3) group receiving fructose 10%, and 4,5) receiving fructose and 100mg/kg or 200mg/kg of extract (n=8). In all groups, before and during the test period, SBP and HR were measured by Power lab system. Lipid profiles were determined by auto analysis. Repeated measurement and one way ANOVA were used for data analysis. P<0.05 was considered statistically significant.
resultsThe SBP in the fructose group significantly increased compared to control group (P<0.01). SBP, in groups receiving fructose+100mg/kg extract, fructose and receiving 200mg/kg extract, and receiving 200mg/kg of extract, compared to fructose group significantly decreased. Heart rate in any of these groups showed no significant difference. Cholesterol, triglyceride, LDL and VLDL in the fructose group significantly increased; however, these effects significantly decreased in the recipient extract groups. HDL levels in the fructose group showed no difference while in the groups receiving the extract they significantly increased.
conclusionsCelery leaf extract reduces SBP, cholesterol, triglyceride, LDL and VLDL in animal model of fructose-induced hypertension. In conclusion, celery leaf extract with its blood pressure and lipid lowering effects, can be considered as an antihypertensive agent in chronic treatment of elevated SBP.
Indexed as
Identifiers
26101753PMC4469955W1962418961What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.