Evidence map›Paper›PMID 26101530›Full record

ArticleInternational journal of pediatrics2015

Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication.

Helen C Atkinson, Julie A Marsh, Shoshana R Rath, Rishi S Kotecha, Hazel Gough, Mandy Taylor, Thomas Walwyn, Nicholas G Gottardo, Catherine H Cole, Catherine S Choong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Pediatric Bone Mineral Accrual Z-Score Calculation Equations and Their Application in Childhood Disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Helen C AtkinsonSchool of Paediatrics and Child Health, The University of Western Australia, Perth, WA 6009, Australia.
Julie A MarshTelethon Kids Institute, The University of Western Australia, Perth, WA 6008, Australia.
Shoshana R RathSchool of Paediatrics and Child Health, The University of Western Australia, Perth, WA 6009, Australia ; Department of Endocrinology, Princess Margaret Hospital, Perth, WA 6008, Australia.
Rishi S KotechaSchool of Paediatrics and Child Health, The University of Western Australia, Perth, WA 6009, Australia ; Telethon Kids Institute, The University of Western Australia, Perth, WA 6008, Australia ; Department of Oncology and Haematology, Princess Margaret Hospital, Perth, WA 6008, Australia.
Hazel GoughDepartment of Oncology and Haematology, Princess Margaret Hospital, Perth, WA 6008, Australia.ORCID 0000-0003-3745-4201
Mandy TaylorDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.ORCID 0000-0001-7669-6081
Thomas WalwynDepartment of Oncology and Haematology, Princess Margaret Hospital, Perth, WA 6008, Australia.ORCID 0000-0003-1461-4612
Nicholas G GottardoSchool of Paediatrics and Child Health, The University of Western Australia, Perth, WA 6009, Australia ; Telethon Kids Institute, The University of Western Australia, Perth, WA 6008, Australia ; Department of Oncology and Haematology, Princess Margaret Hospital, Perth, WA 6008, Australia.
Catherine H ColeSchool of Paediatrics and Child Health, The University of Western Australia, Perth, WA 6009, Australia ; Telethon Kids Institute, The University of Western Australia, Perth, WA 6008, Australia ; Department of Oncology and Haematology, Princess Margaret Hospital, Perth, WA 6008, Australia ; PathWest, Perth, WA 6008, Australia.
Catherine S ChoongSchool of Paediatrics and Child Health, The University of Western Australia, Perth, WA 6009, Australia ; Department of Endocrinology, Princess Margaret Hospital, Perth, WA 6008, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective & Design. We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols (n = 80) to determine longitudinal changes in body mass index (BMI) and the prevalence of obesity compared with a healthy reference population. Results. At diagnosis, the majority of patients (77.5%) were in the healthy weight category. During treatment, increases in BMI z-scores were greater for females than males; the prevalence of obesity increased from 10.3% to 44.8% (P < 0.004) for females but remained relatively unchanged for males (9.8% to 13.7%, P = 0.7). Longitudinal analysis using linear mixed-effects identified associations between BMI z-scores and time-dependent interactions with sex (P = 0.0005), disease risk (P < 0.0001), age (P = 0.0001), and BMI z-score (P < 0.0001) at diagnosis and total dose of steroid during maintenance (P = 0.01). Predicted mean BMI z-scores at the end of therapy were greater for females with standard risk ALL irrespective of age at diagnosis and for males younger than 4 years of age at diagnosis with standard risk ALL. Conclusion. Females treated on standard risk protocols and younger males may be at greatest risk of becoming obese during treatment for ALL. These subgroups may benefit from intervention strategies to manage BMI during treatment for ALL.

Identifiers

PMID26101530
PMCPMC4458559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.