ArticlePakistan journal of medical sciences
Differential immune cell densities in ductal carcinoma In-Situ and invasive breast cancer: Possible role of leukocytes in early stages of carcinogenesis.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Prognostic role of immune infiltrates in breast ductal carcinoma in situ.Breast cancer research and treatment · 2019Review
- Immune Escape in Breast Cancer DuringCancer discovery · 2017Article
- Increased Tumour Infiltration of CD4+ and CD8+ T-Lymphocytes in Patients with Triple Negative Breast Cancer Suggests Susceptibility to Immune TherapyAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Differential Immune Landscape of Hepatocellular Carcinoma Suggests Potential role of Macrophages in Hepatocarcinogenesis.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate immune cell densities in pre-neoplastic (DCIS), cancer (IDC) and control breast tissues.
methodsA total of four preneoplastic, 104 cancer and 104 control samples were analyzed. Morphological classification and prognostic scoring along with quantification of immune cells/mm(2) was performed. Data were entered and analyzed using SPSS version 16. Correlation of immune cell densities with various tumour sub-types was investigated using paired t-test and ANOVA. A p-value of <0.05 was considered as significant.
resultsOur data show increased infiltration of lymphocytes (mean lymphocytes = 287.6cells/mm(2)) as well as myelocytes (mean lymphocytes = 117.1cells/mm(2)) in pre-neoplastic tissues. This infiltration was significantly high compared to cancer (p-value<0.001) as well as control tissues (p-value <0.001). Moreover, we report increased infiltration of lymphocytes in cancer tissues compared to controls (p-value<0.001). There was no difference in lymphocyte densities within various tumour sub-types (all p-values >0.05).
conclusionLeukocytes may play a role in early stages of breast carcinogenesis.
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