Evidence map›Paper›PMID 26101358›Full record

SynthesisPediatrics2015

Systematic Review on Intensive Interdisciplinary Pain Treatment of Children With Chronic Pain.

Tanja Hechler, Marie Kanstrup, Amy Lewandowski Holley, Laura E Simons, Rikard Wicksell, Gerrit Hirschfeld, Boris Zernikow

2 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04561401 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Can Brain Stimulation Enhance Outcomes Associated With Intensive Rehabilitation for Youth With Chronic Pain?

TypeinterventionalSponsorUniversity of CalgaryRan2020 to 2028Enrolled25ConditionsChronic PainArmsRepeated Transcranial Magnetic Stimulation (rTMS), Intensive Pain Rehabilitation Program (IPRP)
NCT06387758 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease

TypeinterventionalSponsorUniversity of Mississippi Medical CenterRan2023 to 2025Enrolled60ConditionsSickle Cell Anemia in ChildrenArmsLow systemic strength training, Moderate systemic exercise
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tanja HechlerGerman Paediatric Pain Centre, Children's Hospital Datteln, Department of Children's Pain Therapy and Paediatric Palliative Care, Faculty of Health-School of Medicine, Witten/Herdecke University, Witten, Germany; t.hechler@deutsches-kinderschmerzzentrum.de.
Marie KanstrupBehavior Medicine Pain Treatment Services, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;
Amy Lewandowski HolleyDivision of Psychology, Institute on Development and Disability, Oregon Health and Science University, Portland, Oregon;
Laura E SimonsBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts; and.
Rikard WicksellBehavior Medicine Pain Treatment Services, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;
Gerrit HirschfeldGerman Paediatric Pain Centre, Children's Hospital Datteln, Department of Children's Pain Therapy and Paediatric Palliative Care, Faculty of Health-School of Medicine, Witten/Herdecke University, Witten, Germany; University of Applied Sciences, Osnabrueck, Osnabrueck, Germany.
Boris ZernikowGerman Paediatric Pain Centre, Children's Hospital Datteln, Department of Children's Pain Therapy and Paediatric Palliative Care, Faculty of Health-School of Medicine, Witten/Herdecke University, Witten, Germany;

Funding

Chronic Pain in Pediatric Primary CareK23HD071946 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI LEWANDOWSKI HOLLEY, AMY S · 2012 to 2016
$583k
NICHD NIH HHS K23 HD071946
6 · The paper itself

Abstract

BACKGROUND AND

objectivePediatric debilitating chronic pain is a severe health problem, often requiring complex interventions such as intensive interdisciplinary pain treatment (IIPT). Research is lacking regarding the effectiveness of IIPT for children. The objective was to systematically review studies evaluating the effects of IIPT.

methodsCochrane, Medline/Ovid, PsycInfo/OVID, PubMed, PubPsych, and Web of Science were searched. Studies were included if (1) treatment was coordinated by ≥3 health professionals, (2) treatment occurred within an inpatient/day hospital setting, (3) patients were <22 years, (4) patients experienced debilitating chronic pain, (5) the study was published in English, and (6) the study had ≥10 participants at posttreatment. The child's pain condition, characteristics of the IIPT, and 5 outcome domains (pain intensity, disability, school functioning, anxiety, depressive symptoms) were extracted at baseline, posttreatment, and follow-up.

resultsOne randomized controlled trial and 9 nonrandomized treatment studies were identified and a meta-analysis was conducted separately on pain intensity, disability, and depressive symptoms revealing positive treatment effects. At posttreatment, there were large improvements for disability, and small to moderate improvements for pain intensity and depressive symptoms. The positive effects were maintained at short-term follow-up. Findings demonstrated extreme heterogeneity.

conclusionsEffects in nonrandomized treatment studies cannot be attributed to IIPT alone. Because of substantial heterogeneity in measures for school functioning and anxiety, meta-analyses could not be computed. There is preliminary evidence for positive treatment effects of IIPT, but the small number of studies and their methodological weaknesses suggest a need for more research on IIPTs for children.

Indexed as

Patient Care TeamAdolescentAnxietyChildChild, PreschoolChildren with DisabilitiesChronic PainDepressionHumansPain Management

Identifiers

PMID26101358
PMCPMC9923588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.