ArticlePediatrics2015
Antibiotic Choice for Children Hospitalized With Pneumonia and Adherence to National Guidelines.
Article in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Use of interrupted time series methods in the evaluation of health system quality improvement interventions: a methodological systematic review.BMJ global health · 2020Pooled it
- Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Trial
- Article
- An Algorithm to Assess Guideline Concordance of Antibiotic Choice in Community-Acquired Pneumonia.Hospital pediatrics · 2024Article
- Management of Pediatric Pneumonia: A Decade After the Pediatric Infectious Diseases Society and Infectious Diseases Society of America Guideline.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Evaluation of a Pediatric Community-Acquired Pneumonia Antimicrobial Stewardship Intervention at an Academic Medical Center.Antibiotics (Basel, Switzerland) · 2023Article
- Epidemiology and mortality predictors for severe childhood community-acquired pneumonia in ICUs: A retrospective observational study.Frontiers in pediatrics · 2023Article
- The development of a novel natural language processing tool to identify pediatric chest radiograph reports with pneumonia.Frontiers in digital health · 2023Article
- Association Between Procalcitonin and Antibiotics in Children With Community-Acquired Pneumonia.Hospital pediatrics · 2022Article
- Macrolides (alone or in combination) should be used as first-line empirical therapy of community-acquired pneumonia in children: myth or maxim?Breathe (Sheffield, England) · 2021Article
- Combined influence of practice guidelines and prospective audit and feedback stewardship on antimicrobial treatment of community-acquired pneumonia and empyema in children: 2012 to 2016.Paediatrics & child health · 2021Article
- Ambulatory Antibiotic Prescribing for Children with Pneumonia After Publication of National Guidelines: A Cross-Sectional Retrospective Study.Infectious diseases and therapy · 2020Article
- Improving antibiotic prescribing in the emergency department for uncomplicated community-acquired pneumonia.World journal of emergency medicine · 2020Article
- Facilitators of interdepartmental quality improvement: a mixed-methods analysis of a collaborative to improve pediatric community-acquired pneumonia management.BMJ quality & safety · 2019Article
- Patterns of Care Related to Post-Operative Radiotherapy for Patients with Prostate Cancer among Canadian Radiation Oncologists and Urologists.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Article
- Development and Validation of a Model to Predict Growth of Potentially Antibiotic-Resistant Gram-Negative Bacilli in Critically Ill Children With Suspected Infection.Open forum infectious diseases · 2018Article
- Effectiveness of β-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia.JAMA pediatrics · 2017Observational
- Knowledge, attitude and practice of antibiotic use and misuse among adults in Riyadh, Saudi Arabia.Saudi medical journal · 2017Article
- Article
- Treatment of Community-Acquired Pneumonia: Are All Countries Treating Children in the Same Way? A Literature Review.International journal of pediatrics · 2017Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
introductionThe 2011 national guidelines for the management of childhood community-acquired pneumonia (CAP) recommended narrow-spectrum antibiotics (eg, ampicillin) for most children hospitalized with CAP. We assessed the impact of these guidelines on antibiotic prescribing at 3 children's hospitals.
methodsChildren hospitalized with clinical and radiographic CAP were enrolled from January 1, 2010, through June 30, 2012, at 3 hospitals in Tennessee and Utah as part of the Centers for Disease Control and Prevention Etiology of Pneumonia in the Community study. Antibiotic selection was determined by the treating provider. The impact of the guidelines and hospital-level implementation efforts was determined by assessing the monthly percentage of enrolled children receiving third-generation cephalosporins or penicillin/ampicillin. Segmented linear regression was used to compare observed antibiotic selection in the postguideline period with expected antibiotic use projected from preguideline months.
resultsOverall, 2121 children were included. During the preguideline period, 52.8% (interquartile range 47.8-56.6) of children with CAP received third-generation cephalosporins, whereas 2.7% (2.1, 7.0) received penicillin/ampicillin. By 9 months postguidelines, third-generation cephalosporin use declined (absolute difference -12.4% [95% confidence interval -19.8% to -5.1%]), whereas penicillin/ampicillin use increased (absolute difference 11.3% [4.3%-18.3%]). The most substantial changes were noted at those institutions that implemented guideline-related dissemination activities.
conclusionsAfter publication of national guidelines, third-generation cephalosporin use declined and penicillin/ampicillin use increased among children hospitalized with CAP. Changes were more apparent among those institutions that proactively disseminated the guidelines, suggesting that targeted, hospital-based efforts are important for timely implementation of guideline recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.