ArticleHypertension (Dallas, Tex. : 1979)2015
Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women.
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Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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36citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 3% of its field
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The effects of oral contraceptives on resting autonomic function and the autonomic response to physiological stressors: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Menstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Pooled it
- Does Gender Influence the Relationship Between High Blood Pressure and Dementia? Highlighting Areas for Further Investigation.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022Trial
- The Impact of Serum Oestradiol and Progesterone Levels on Intraocular Pressure and Systemic Health: Hormonal and Physiological Interactions in Female Dogs.Veterinary medicine and science · 2026Article
- Hypertension in Women Across the Life Cycle: Unique Aspects and Challenges.Current hypertension reports · 2026Review
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Elevated blood pressure, stroke volume, and vascular tone in young women who use oral contraception.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
- The role of peripheral venous distension reflex in regulating hemodynamics: mini review.Autonomic neuroscience : basic & clinical · 2024Review
- Influence of endogenous and exogenous hormones on the cardiovascular response to lower extremity exercise and group III/IV activation in young females.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Sympathetic and blood pressure reactivity in young adults with major depressive disorder.Journal of affective disorders · 2024Article
- The influence of oral contraceptives on the exercise pressor reflex in the upper and lower body.Physiological reports · 2024Article
- Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia.American journal of physiology. Heart and circulatory physiology · 2024Article
- The role of arousal in maintaining the relationship between insomnia and gastrointestinal conditions.Translational gastroenterology and hepatology · 2024Review
- Trimethylamine N-Oxide Concentration and Blood Pressure in Young Healthy Men and Women: A Replicated Crossover Study.Metabolites · 2023Article
- Oral Contraceptive Pills and Hypertension: A Review of Current Evidence and Recommendations.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.American journal of physiology. Heart and circulatory physiology · 2023Article
- Menstrual phase does not influence ventilatory responses to group III/IV afferent signaling in eumenorrheic young females.Respiratory physiology & neurobiology · 2021Article
- The Specificities of Elite Female Athletes: A Multidisciplinary Approach.Life (Basel, Switzerland) · 2021Review
- Integrative cardiovascular control in women: Regulation of blood pressure, body temperature, and cerebrovascular responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Ronee E HarveyFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.). harvey.ronee@mayo.edu.
Emma C HartFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
Nisha CharkoudianFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
Timothy B CurryFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
Jason R CarterFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
Qi FuFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
Christopher T MinsonFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
Michael J JoynerFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
Jill N BarnesFrom the Department of Anesthesiology, Mayo Clinic, Rochester, MN (R.E.H., T.B.C., M.J.J., J.N.B.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (E.C.H.); Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA (N.C.); Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton (J.R.C.); Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center (Q.F.); and Department of Human Physiology, University of Oregon, Eugene (C.T.M.).
United States Army · USThe University of Texas Southwestern Medical Center · USInstitute for Exercise and Environmental Medicine · USMichigan Technological University · USPresbyterian Hospital · USUniversity of Bristol · GB
Funding
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2MPERFUSION OF ACTIVE MUSCLES--METABOLITES AND NERVESR01HL046493 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 1997 to 2011
$3.7MNeurovascular Control and Blood Pressure Regulation in HumansR01HL083947 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2007 to 2016
$3.6MProgesterone and Vascular Function in WomenR01HL081671 · NHLBI · UNIVERSITY OF OREGON · PI MINSON, CHRISTOPHER TODD · 2008 to 2011
$1.3MCerebral blood flow, connectivity and cognition: the effect of age and exerciseR00HL118154 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BARNES, JILL NICOLE · 2015 to 2017
$735kGender &orthostatic intolerance: mechanisms and therapyK23HL075283 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI FU, QI · 2004 to 2008
$622kSympathetic activation: a link ot the metabolic syndromeK23DK082424 · NIDDK · MAYO CLINIC ROCHESTER · PI CURRY, TIMOTHY BRIAN · 2008 to 2011
$621kSleep deprivation and neurovascular control in humansR21HL098676 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI CARTER, JASON R · 2010 to 2011
$426kFish oil and neurovascular control in humansR15HL088689 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI CARTER, JASON R · 2008 to 2009
$232kCerebral blood flow, connectivity and cognition: the effect of age and exerciseK99HL118154 · NHLBI · MAYO CLINIC ROCHESTER · PI BARNES, JILL NICOLE · 2014 to 2015
$180kBrain Vasodilator Responses in Healthy and Cognitively Impaired HumansF32AG038067 · NIA · MAYO CLINIC ROCHESTER · PI BARNES, JILL NICOLE · 2011 to 2012
$69kMENSTRUAL CYCLE AND CARDIOVASCULAR CONTROL IN WOMENF32HL010123 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI MINSON, CHRISTOPHER TODD · 1999 to 2000
$23kBritish Heart Foundation FS/11/1/28400NCATS NIH HHS UL1 TR000135NHLBI NIH HHS F32 HL010123NHLBI NIH HHS HL081671NHLBI NIH HHS HL083947NHLBI NIH HHS HL088689NHLBI NIH HHS HL098676NHLBI NIH HHS HL10123NHLBI NIH HHS HL118154NHLBI NIH HHS HL46493NHLBI NIH HHS K23 HL075283NHLBI NIH HHS K99 HL118154NHLBI NIH HHS R00 HL118154NHLBI NIH HHS R01 HL046493NHLBI NIH HHS R01 HL081671NHLBI NIH HHS R01 HL083947NHLBI NIH HHS R15 HL088689NHLBI NIH HHS R21 HL098676NIA NIH HHS AG38067NIA NIH HHS F32 AG038067NIDDK NIH HHS DK082424NIDDK NIH HHS K23 DK082424
Abstract
Endogenous female sex hormones influence muscle sympathetic nerve activity (MSNA), a regulator of arterial blood pressure and important factor in hypertension development. Although ≈80% of American women report using hormonal contraceptives sometime during their life, the influence of combined oral contraceptives (OCs) on MSNA and systemic hemodynamics remains equivocal. The goal of this study was to determine whether women taking OCs have altered MSNA and hemodynamics (cardiac output and total peripheral resistance) at rest during the placebo phase of OC use compared with women with natural menstrual cycles during the early follicular phase. We retrospectively analyzed data from studies in which healthy, premenopausal women (aged 18-35 years) participated. We collected MSNA values at rest and hemodynamic measurements in women taking OCs (n=53; 25±4 years) and women with natural menstrual cycles (n=74; 25±4 years). Blood pressure was higher in women taking OCs versus those with natural menstrual cycles (mean arterial pressure, 89±1 versus 85±1 mm Hg, respectively; P=0.01), although MSNA was similar in both groups (MSNA burst incidence, 16±1 versus 18±1 bursts/100 heartbeats, respectively; P=0.19). In a subset of women in which detailed hemodynamic data were available, those taking OCs (n=33) had similar cardiac output (4.9±0.2 versus 4.7±0.2 L/min, respectively; P=0.47) and total peripheral resistance (19.2±0.8 versus 20.0±0.9 U, respectively; P=0.51) as women with natural menstrual cycles (n=22). In conclusion, women taking OCs have higher resting blood pressure and similar MSNA and hemodynamics during the placebo phase of OC use when compared with naturally menstruating women in the early follicular phase.
Indexed as
AdolescentAdultBlood PressureContraceptives, Oral, HormonalFemaleHemodynamicsHumansMenstrual CycleMuscle, SkeletalSympathetic Nervous SystemVascular ResistanceYoung AdultContraceptives, Oral, Hormonalblood pressurefollicular phasehemodynamicshypertensionoral contraceptives
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