GuidelineJournal of feline medicine and surgery2015
Feline injection-site sarcoma: ABCD guidelines on prevention and management.
Guideline in Journal of feline medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- WSAVA Guidelines for the vaccination of dogs and cats.The Journal of small animal practice · 2016Guideline
- Apoptosis inhibitor of macrophage (AIM/CD5L) as a potential immunomodulator in feline injection-site sarcoma: a hypothesis on tumor-macrophage interactions.The veterinary quarterly · 2026Review
- From human allergen immunotherapy to veterinary prophylactic vaccines: translational potential of Microcrystalline tyrosine as a vaccine adjuvant.Veterinary research communications · 2026Review
- Antibody responses to inactivated (adjuvanted) and attenuated (non-adjuvanted) feline panleukopaenia virus vaccination, including in different injection sites.Journal of feline medicine and surgery · 2026Article
- Pilot Study of Partial Tumor Ablation Using Thermal High-Intensity Focused Ultrasound (HIFU) in Feline Soft Tissue Sarcomas.Animals : an open access journal from MDPI · 2026Article
- A Rare Case of Malignant Plasmacytoma at a Previous Injection Site in a Cat.Veterinary sciences · 2026Article
- Case Report: Nasal acinic cell carcinoma in a cat: clinicopathological and immunohistochemical characterization of a rare neoplasm.Frontiers in veterinary science · 2026Article
- Retrospective Analysis of Prevalence of Tumors in Dogs and Cats in Lithuania.Veterinary sciences · 2025Article
- Modified aluminum (Al)-hematoxylin stain for detection of Al in sheep and cat tissues: an animal model for the study of Al-associated conditions.Veterinary research communications · 2025Article
- Expression of αAnimals : an open access journal from MDPI · 2024Article
- Antibody response after feline panleukopenia virus vaccination in kittens with and without intestinal parasites.Journal of feline medicine and surgery · 2024Article
- Comparison of MMP-2, MMP-9, COX-2, and PGP Expression in Feline Injection-Site and Feline Noninjection-Site Sarcomas-Pilot Study.Animals : an open access journal from MDPI · 2024Article
- Anti-rabies humoral immune response in cats after concurrent vs separate vaccination against rabies and feline leukaemia virus using canarypox-vectored vaccines.Journal of feline medicine and surgery · 2024Article
- A Comparison of the Intrarectal and Intramuscular Effects of a Dexmedetomidine, Ketamine and Midazolam Mixture on Tear Production in Cats: A Randomized Controlled Trial.Animals : an open access journal from MDPI · 2023Article
- Prevalence of Serum Antibody Titers against Core Vaccine Antigens in Italian Cats.Life (Basel, Switzerland) · 2023Article
- A Scoping Review on Tyrosine Kinase Inhibitors in Cats: Current Evidence and Future Directions.Animals : an open access journal from MDPI · 2023Article
- Stem cell pathology: histogenesis of malignant fibrous histiocytoma and characterization of myofibroblasts appearing in fibrotic lesions.The Journal of veterinary medical science · 2023Review
- Review
- Metallothionein expression in feline injection site fibrosarcomas.BMC veterinary research · 2023Article
- Feline Oncogenomics: What Do We Know about the Genetics of Cancer in Domestic Cats?Veterinary sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
overviewIn cats, the most serious of adverse effects following vaccination is the occurrence of invasive sarcomas (mostly fibrosarcomas): so-called 'feline injection-site sarcomas' (FISSs). These develop at sites of previous vaccination or injection. They have characteristics that are distinct from those of fibrosarcomas in other areas and behave more aggressively. The rate of metastasis ranges from 10-28%. PATHOGENESIS: The pathogenesis of these sarcomas is not yet definitively explained. However, chronic inflammatory reactions are considered the trigger for subsequent malignant transformation. Injections of long-acting drugs (such as glucocorticoids, and others) have been associated with sarcoma formation. Adjuvanted vaccines induce intense local inflammation and seem therefore to be particularly linked to the development of FISS. The risk is lower for modified-live and recombinant vaccines, but no vaccine is risk-free. TREATMENT AND PREVENTION: Aggressive, radical excision is required to avoid tumour recurrence. The prognosis improves if additional radiotherapy and/or immunotherapy (such as recombinant feline IL-2) are used. For prevention, administration of any irritating substance should be avoided. Vaccination should be performed as often as necessary, but as infrequently as possible. Non-adjuvanted, modified-live or recombinant vaccines should be selected in preference to adjuvanted vaccines. Injections should be given at sites at which surgery would likely lead to a complete cure; the interscapular region should generally be avoided. Post-vaccination monitoring should be performed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.