Evidence map›Paper›PMID 26101305›Full record

ArticleSchizophrenia bulletin2016

Neurocognition and Duration of Psychosis: A 10-year Follow-up of First-Episode Patients.

Bjørn Rishovd Rund, Helene Eidsmo Barder, Julie Evensen, Ulrik Haahr, Wenche ten Velden Hegelstad, Inge Joa, Jan Olav Johannessen, Johannes Langeveld, Tor Ketil Larsen, Ingrid Melle and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Bjørn Rishovd RundVestre Viken Hospital Trust, Drammen, Norway; Department of Psychology, University of Oslo, Oslo, Norway; b.r.rund@psykologi.uio.no.
Helene Eidsmo BarderDepartment of Psychology, University of Oslo, Oslo, Norway;
Julie EvensenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway;
Ulrik HaahrEarly Psychosis Intervention Center, Psychiatry East, Region Zealand, Roskilde, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;
Wenche ten Velden HegelstadCentre for Clinical Research in Psychosis, Psychiatric Division, Stavanger University Hospital, Stavanger, Norway;
Inge JoaCentre for Clinical Research in Psychosis, Psychiatric Division, Stavanger University Hospital, Stavanger, Norway; Faculty of Social Science,University of Stavanger, Stavanger, Norway;
Jan Olav JohannessenCentre for Clinical Research in Psychosis, Psychiatric Division, Stavanger University Hospital, Stavanger, Norway; Faculty of Social Science,University of Stavanger, Stavanger, Norway;
Johannes LangeveldCentre for Clinical Research in Psychosis, Psychiatric Division, Stavanger University Hospital, Stavanger, Norway;
Tor Ketil LarsenCentre for Clinical Research in Psychosis, Psychiatric Division, Stavanger University Hospital, Stavanger, Norway; Institute of Psychiatry, University of Bergen, Bergen, Norway;
Ingrid MelleDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway;
Stein OpjordsmoenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway;
Jan Ivar RøssbergDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway;
Erik SimonsenEarly Psychosis Intervention Center, Psychiatry East, Region Zealand, Roskilde, Denmark; Psychiatric Research Unit, Psychiatry Region Zealand, Roskilde, Denmark.
Kjetil SundetDepartment of Psychology, University of Oslo, Oslo, Norway; NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway;
Per VaglumDepartment of Behavioural Sciences in Medicine, University of Oslo, Oslo, Norway.
Thomas McGlashanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT.
Svein FriisDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway;
Oslo University Hospital · NOStavanger University Hospital · NOUniversity of Oslo · NORegion Zealand · DKYale University · US

Funding

EARLY DETECTION AND INTERVENTION IN PSYCHOSISK05MH001654 · NIMH · YALE UNIVERSITY · PI MCGLASHAN, THOMAS HAMEL · 1999 to 2003
$500k
NIMH NIH HHS MH-01654
6 · The paper itself

Abstract

A substantial proportion of schizophrenia-spectrum patients exhibit a cognitive impairment at illness onset. However, the long-term course of neurocognition and a possible neurotoxic effect of time spent in active psychosis, is a topic of controversy. Furthermore, it is of importance to find out what predicts the long-term course of neurocognition. Duration of untreated psychosis (DUP), accumulated time in psychosis the first year after start of treatment, relapse rates and symptoms are potential predictors of the long-term course. In this study, 261 first-episode psychosis patients were assessed neuropsychologically on one or more occasions. Patients were tested after remission of psychotic symptoms and reassessed 1, 2, 5, and 10 years after inclusion. The neurocognitive battery consisted of California Verbal Learning Test, Wisconsin Card Sorting Test, Controlled Oral Word Association Task, Trail Making A and B, and Finger Tapping. We calculated a composite score by adding the z-scores of 4 tests that were only moderately inter-correlated, not including Finger Tapping. Data were analyzed by a linear mixed model. The composite score was stable over 10 years. No significant relationship between psychosis before (DUP) or after start of treatment and the composite score was found, providing no support for the neurotoxicity hypothesis, and indicating that psychosis before start of treatment has no significant impact on the course and outcome in psychosis. We found no association between symptoms and the neurocognitive trajectory. Stable remission during the first year predicted neurocognitive functioning, suggesting that the early clinical course is a good predictor for the long-term course.

Indexed as

Schizophrenic PsychologyAdolescentAdultAffective Disorders, PsychoticAgedCognition DisordersFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsProspective StudiesPsychotic DisordersRecurrenceDUPneurocognitionneurotoxicityrelapseschizophreniasymptoms

Identifiers

PMID26101305
PMCPMC4681546
OpenAlexW1848195443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.