ArticleThe American journal of tropical medicine and hygiene2015
Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025Review
- Thalassemia in Bangladesh: progress, challenges, and a strategic blueprint for prevention.Orphanet journal of rare diseases · 2025Review
- Knowledge and attitudes of thalassaemia among high-risk indigenous university students in Bangladesh: A pilot study.PloS one · 2023Article
- Precarity at the Margins of Malaria Control in the Chittagong Hill Tracts in Bangladesh: A Mixed-Methods Study.Pathogens (Basel, Switzerland) · 2020Article
- Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh.The American journal of tropical medicine and hygiene · 2020Article
- Incidental screen positive findings in a prospective cohort study in Matlab, Bangladesh: insights into expanded newborn screening for low-resource settings.Orphanet journal of rare diseases · 2019Article
- Hemoglobin E, malaria and natural selection.Evolution, medicine, and public health · 2019Review
- Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border.The Journal of infection · 2018Article
- Thalassemias in South Asia: clinical lessons learnt from Bangladesh.Orphanet journal of rare diseases · 2017Review
- Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria.Malaria journal · 2017Observational
- Article
- A Comparison of Three Quantitative Methods to Estimate G6PD Activity in the Chittagong Hill Tracts, Bangladesh.PloS one · 2017Article
- Prevalence and hematological indicators of G6PD deficiency in malaria-infected patients.Infectious diseases of poverty · 2016Article
- Article
- G6PD Deficiency and Antimalarial Efficacy for Uncomplicated Malaria in Bangladesh: A Prospective Observational Study.PloS one · 2016Observational
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Authors and funding
15 authors at 1 institution in 1 country.
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Abstract
Hemoglobin E is largely confined to south and southeast Asia. The association between hemoglobin E (HbE) and malaria is less clear than that of hemoglobin S and C. As part of a malaria study in the Chittagong Hill Districts of Bangladesh, an initial random sample of 202 individuals showed that 39% and 49% of Marma and Khyang ethnic groups, respectively, were positive for either heterozygous or homozygous hemoglobin E. In this group, 6.4% were also found to be severely deficient and 35% mildly deficient for glucose-6-phosphate dehydrogenase (G6PD). In a separate Plasmodium falciparum malaria case-uninfected control study, the odds of having homozygous hemoglobin E (HbEE) compared with normal hemoglobin (HbAA) were higher among malaria cases detected by passive surveillance than age and location matched uninfected controls (odds ratio [OR] = 5.0, 95% confidence interval [CI] = 1.07-46.93). The odds of heterozygous hemoglobin E (HbAE) compared with HbAA were similar between malaria cases and uninfected controls (OR = 0.71, 95% CI = 0.42-1.19). No association by hemoglobin type was found in the initial parasite density or the proportion parasite negative after 2 days of artemether/lumefantrine treatment. HbEE, but not HbAE status was associated with increased passive case detection of malaria.
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