ArticleNucleic acids research2015
microRNAs and the evolution of complex multicellularity: identification of a large, diverse complement of microRNAs in the brown alga Ectocarpus.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Germline fate determination by a single ARGONAUTE protein inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Characterization of the transposable element landscape shaping the Ectocarpus genome.Genome biology · 2025Article
- Review
- Evolution of microRNAs in Amoebozoa and implications for the origin of multicellularity.Nucleic acids research · 2024Article
- Small RNAs in Cnidaria: A review.Evolutionary applications · 2023Article
- Comparative transcriptome analysis, unfolding the pathways regulating the seed-size trait in cultivated lentil (Frontiers in genetics · 2022Article
- Review
- Histone modifications during the life cycle of the brown alga Ectocarpus.Genome biology · 2021Article
- Diatom Molecular Research Comes of Age: Model Species for Studying Phytoplankton Biology and Diversity.The Plant cell · 2020Review
- Non-Coding RNAs Participate in the Regulation ofInternational journal of molecular sciences · 2020Article
- Presence of Exogenous Sulfate Is Mandatory for Tip Growth in the Brown AlgaFrontiers in plant science · 2020Article
- Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease.Cell metabolism · 2019Review
- Too Many False Targets for MicroRNAs: Challenges and Pitfalls in Prediction of miRNA Targets and Their Gene Ontology in Model and Non-model Organisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes.PLoS genetics · 2018Article
- Article
- DISTAG/TBCCd1 Is Required for Basal Cell Fate Determination inThe Plant cell · 2017Article
- miRNAs in the alga Chlamydomonas reinhardtii are not phylogenetically conserved and play a limited role in responses to nutrient deprivation.Scientific reports · 2017Article
- Rapid Evolution of microRNA Loci in the Brown Algae.Genome biology and evolution · 2017Article
- The evolutionary origin of plant and animal microRNAs.Nature ecology & evolution · 2017Article
- Pervasive microRNA Duplication in Chelicerates: Insights from the Embryonic microRNA Repertoire of the Spider Parasteatoda tepidariorum.Genome biology and evolution · 2016Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is currently convincing evidence that microRNAs have evolved independently in at least six different eukaryotic lineages: animals, land plants, chlorophyte green algae, demosponges, slime molds and brown algae. MicroRNAs from different lineages are not homologous but some structural features are strongly conserved across the eukaryotic tree allowing the application of stringent criteria to identify novel microRNA loci. A large set of 63 microRNA families was identified in the brown alga Ectocarpus based on mapping of RNA-seq data and nine microRNAs were confirmed by northern blotting. The Ectocarpus microRNAs are highly diverse at the sequence level with few multi-gene families, and do not tend to occur in clusters but exhibit some highly conserved structural features such as the presence of a uracil at the first residue. No homologues of Ectocarpus microRNAs were found in other stramenopile genomes indicating that they emerged late in stramenopile evolution and are perhaps specific to the brown algae. The large number of microRNA loci in Ectocarpus is consistent with the developmental complexity of many brown algal species and supports a proposed link between the emergence and expansion of microRNA regulatory systems and the evolution of complex multicellularity.
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