Evidence map›Paper›PMID 26101247›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer.

Kutluk Oktay, Volkan Turan, Giuliano Bedoschi, Fernanda S Pacheco, Fred Moy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 10 pooled it
24.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 10 syntheses or guidelines pooled it, 221 citations in OpenAlex.

  1. Pooled it
  2. Cancer and fertility management: FIGO best practice advice.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Guideline
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  15. Fertility in breast cancer survivorship: a scoping review.Journal of cancer survivorship : research and practice · 2026
    Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kutluk OktayKutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY. koktay@fertilitypreservation.org.
Volkan TuranKutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
Giuliano BedoschiKutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
Fernanda S PachecoKutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
Fred MoyKutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
New York Medical College · US

Funding

Characterization & Prevention of Chemotherapy-Induced Damage to Ovarian ReserveR01HD053112 · NICHD · YALE UNIVERSITY · PI KUTLUK H OKTAY · 2007 to 2026
$7.6M
Improving Primordial Follicle Survival After Transplantation of Cryopreserved HumR21HD061259 · NICHD · NEW YORK MEDICAL COLLEGE · PI OKTAY, KUTLUK H · 2011 to 2012
$443k
NICHD NIH HHS R01 HD053112NICHD NIH HHS R21 HD061259
6 · The paper itself

Abstract

purposeWe have previously reported an approach to ovarian stimulation for the purpose of fertility preservation (FP) in women with breast cancer via embryo freezing with the concurrent use of letrozole. The aim of this study was to provide the pregnancy and FP outcomes when embryos generated with the same protocol are used. PATIENTS AND

methodsIn all, 131 women with stage ≤ 3 breast cancer underwent ovarian stimulation and received concurrent letrozole 5 mg per day before receiving adjuvant chemotherapy and cryopreserving embryos.

resultsThirty-three of the 131 women underwent 40 attempts to transfer embryos to their own uterus (n = 18) or via the use of a gestational carrier (n = 22) at a mean age of 41.5 ± 4.3 years with a median 5.25 years after embryo cryopreservation. The overall live birth rate per embryo transfer was similar to the US national mean among infertile women of a similar age undergoing in vitro fertilization-embryo transfer (45.0 v 38.2; P = .2). Seven (38.8%) of the 18 pregnancies were twins with no higher-order pregnancies being encountered. No fetal anomalies or malformations were reported in 25 children after a mean follow-up of 40.4 ± 26.4 months. Seventeen of the 33 women attempting pregnancy had at least one child, translating into an FP rate of 51.5% per attempting woman.

conclusionEmbryo cryopreservation after ovarian stimulation with the letrozole and follicle-stimulating hormone protocol preserves fertility in women with breast cancer and results in pregnancy rates comparable to those expected in a noncancer population undergoing in vitro fertilization.

Indexed as

CryopreservationEmbryo, MammalianOvulation InductionAdultAromatase InhibitorsBreast NeoplasmsFemaleFertility PreservationFollicle Stimulating HormoneFollow-Up StudiesHumansInfertility, FemaleLetrozoleNeoplasm StagingNitrilesPregnancyAromatase InhibitorsFollicle Stimulating HormoneLetrozoleNitrilesTriazoles

Identifiers

PMID26101247
PMCPMC4507464
OpenAlexW2122427886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.