ArticleProceedings of the National Academy of Sciences of the United States of America2015
Synaptic clusters function as odor operators in the olfactory bulb.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neural Influences on Tumor Progression Within the Central Nervous System.CNS neuroscience & therapeutics · 2024Review
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- A GPU-based computational framework that bridges neuron simulation and artificial intelligence.Nature communications · 2023Article
- Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs.Biophysical journal · 2022Article
- Interhemispheric asymmetry of c-Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation.FEBS open bio · 2020Article
- Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring.Particle and fibre toxicology · 2019Article
- Reconstruction and Simulation of a Scaffold Model of the Cerebellar Network.Frontiers in neuroinformatics · 2019Article
- Synaptic Clustering and Memory Formation.Frontiers in molecular neuroscience · 2019Review
- Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.Scientific reports · 2018Article
- IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.Neuron · 2017Article
- Emergence of coupling-induced oscillations and broken symmetries in heterogeneously driven nonlinear reaction networks.Scientific reports · 2017Article
- Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb.Nature communications · 2016Article
- Predicting the response of olfactory sensory neurons to odor mixtures from single odor response.Scientific reports · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Sniff-Like Patterned Input Results in Long-Term Plasticity at the Rat Olfactory Bulb Mitral and Tufted Cell to Granule Cell Synapse.Neural plasticity · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
How the olfactory bulb organizes and processes odor inputs through fundamental operations of its microcircuits is largely unknown. To gain new insight we focus on odor-activated synaptic clusters related to individual glomeruli, which we call glomerular units. Using a 3D model of mitral and granule cell interactions supported by experimental findings, combined with a matrix-based representation of glomerular operations, we identify the mechanisms for forming one or more glomerular units in response to a given odor, how and to what extent the glomerular units interfere or interact with each other during learning, their computational role within the olfactory bulb microcircuit, and how their actions can be formalized into a theoretical framework in which the olfactory bulb can be considered to contain "odor operators" unique to each individual. The results provide new and specific theoretical and experimentally testable predictions.
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