ArticleProceedings of the National Academy of Sciences of the United States of America2015
A self-lysis pathway that enhances the virulence of a pathogenic bacterium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
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- Escherichia coli has an undiscovered ability to inhibit the growth of both Gram-negative and Gram-positive bacteria.Scientific reports · 2024Article
- Facultative symbiont virulence determines horizontal transmission rate without host strain specificity.bioRxiv : the preprint server for biology · 2023Article
- YgfB increases β-lactam resistance in Pseudomonas aeruginosa by counteracting AlpA-mediated ampDh3 expression.Communications biology · 2023Article
- Structural basis for regulation of SOS response in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structural basis of AlpA-dependent transcription antitermination.Nucleic acids research · 2022Article
- A dynamic rhizosphere interplay between tree roots and soil bacteria under drought stress.eLife · 2022Article
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- Sending out an SOS - the bacterial DNA damage response.Genetics and molecular biology · 2022Article
- Article
- A wide-ranging Pseudomonas aeruginosa PeptideAtlas build: A useful proteomic resource for a versatile pathogen.Journal of proteomics · 2021Article
- Control of a programmed cell death pathway in Pseudomonas aeruginosa by an antiterminator.Nature communications · 2021Article
- Multiple holins contribute to extracellular DNA release inMicrobiology (Reading, England) · 2021Article
- Molecular Determinants of Antibiotic Resistance in the Costa RicanPhenomics (Cham, Switzerland) · 2021Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
In mammalian cells, programmed cell death (PCD) plays important roles in development, in the removal of damaged cells, and in fighting bacterial infections. Although widespread among multicellular organisms, there are relatively few documented instances of PCD in bacteria. Here we describe a potential PCD pathway in Pseudomonas aeruginosa that enhances the ability of the bacterium to cause disease in a lung infection model. Activation of the system can occur in a subset of cells in response to DNA damage through cleavage of an essential transcription regulator we call AlpR. Cleavage of AlpR triggers a cell lysis program through de-repression of the alpA gene, which encodes a positive regulator that activates expression of the alpBCDE lysis cassette. Although this is lethal to the individual cell in which it occurs, we find it benefits the population as a whole during infection of a mammalian host. Thus, host and pathogen each may use PCD as a survival-promoting strategy. We suggest that activation of the Alp cell lysis pathway is a disease-enhancing response to bacterial DNA damage inflicted by the host immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.