ArticleNature chemistry2015
An eight-step gram-scale synthesis of (-)-jiadifenolide.
Article in Nature chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 100 citations in OpenAlex.
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- Chloroplast mini-barcodes combined with high resolution melting analysis to identify herbal medicine Difengpi (Heliyon · 2024Article
- Neurotrophic Natural Products.Progress in the chemistry of organic natural products · 2024Article
- Synthesis of Guaipyridine Alkaloids Rupestine M and L by Cycloaddition/Cycloreversion of an Intermediate 1,4-Oxazinone.Synthesis · 2023Article
- Total Synthesis of (+)-Shearilicine.Journal of the American Chemical Society · 2023Article
- Stereodivergent Attached-Ring Synthesis via Non-Covalent Interactions: A Short Formal Synthesis of Merrilactone A.Angewandte Chemie (International ed. in English) · 2022Article
- Anionic Diels-Alder Chemistry of Cyclic Sodium Dien-1-olates Delivering Highly Stereoselective and Functionalized Polycyclic Adducts.Organic letters · 2021Article
- Change the channel: CysLoop receptor antagonists from nature.Pest management science · 2021Review
- Natural Product Synthesis through the Lens of Informatics.Accounts of chemical research · 2021Review
- An invocation for computational evaluation of isomerization transforms: cationic skeletal reorganizations as a case study.Natural product reports · 2021Review
- Enantioselective Total Synthesis of Andrographolide and 14-Hydroxy-Colladonin: Carbonyl Reductive Coupling and trans-Decalin Formation by Hydrogen Transfer.Angewandte Chemie (International ed. in English) · 2020Article
- Synthetic, Mechanistic, and Biological Interrogation ofJournal of the American Chemical Society · 2020Article
- The search for, and chemistry and mechanism of, neurotrophic natural products.Journal of natural medicines · 2020Review
- Contiguous Quaternary Carbons: A Selection of Total Syntheses.Molecules (Basel, Switzerland) · 2020Review
- Total Synthesis Provides Strong Evidence: Xestocyclamine A is the Enantiomer of Ingenamine.Journal of the American Chemical Society · 2020Article
- Synthesis of (-)-Picrotoxinin by Late-Stage Strong Bond Activation.Journal of the American Chemical Society · 2020Article
- Development of a Cross-Conjugated Vinylogous [4+2] Anionic Annulation and Application to the Total Synthesis of Natural Antibiotic (±)-ABX.Angewandte Chemie (International ed. in English) · 2020Article
- Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists.Nature chemistry · 2020Article
- Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes.Journal of the American Chemical Society · 2019Article
- Contemporary Synthetic Strategies toward seco-Prezizaane Sesquiterpenes from Illicium Species.The Journal of organic chemistry · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of a biologically active secondary metabolite into a useful medicine requires continuous access to meaningful quantities of material. Although any chemical synthesis is broadly useful for its versatility, identification of a synthesis route that can be economically scaled represents a greater challenge. Here we report a concise synthesis of the neurotrophic trace metabolite (-)-jiadifenolide and its production on a gram-scale. The brevity of the route and the structural similarity of a key intermediate to many potent Illicium terpenes make chemical synthesis the unquestionable method for accessing and modifying these potential therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.