ArticleGenome biology and evolution2015
The Rise and Fall of TRP-N, an Ancient Family of Mechanogated Ion Channels, in Metazoa.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Bidirectional crosstalk between TRP channels and Toll-like receptors in inflammation and host defense.Journal of neuroinflammation · 2026Review
- Integrative genomic, phylogenetic, and transcriptomic analyses reveal temperature-responsive transient receptor potential (TRP) genes in Pacific abalone Haliotis discus hannai.BMC ecology and evolution · 2026Article
- Piezo proteins, mechano reception and behaviour in Hydra.Scientific reports · 2025Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- Molecular tuning of sea anemone stinging.eLife · 2023Article
- A small molecule screen identifies novel inhibitors of mechanosensory nematocyst discharge in Hydra.Scientific reports · 2021Article
- The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra.BMC biology · 2021Article
- Reafference and the origin of the self in early nervous system evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Transcriptional profiling of identified neurons in leech.BMC genomics · 2021Article
- Bacteria- and temperature-regulated peptides modulate β-catenin signaling inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature.Proceedings. Biological sciences · 2020Article
- Phylogenetics Identifies Two Eumetazoan TRPM Clades and an Eighth TRP Family, TRP Soromelastatin (TRPS).Molecular biology and evolution · 2020Article
- Article
- Diversity of cilia-based mechanosensory systems and their functions in marine animal behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Emergence of a Thrombospondin Superfamily at the Origin of Metazoans.Molecular biology and evolution · 2019Article
- Article
- OSM-9 and an amiloride-sensitive channel, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons.Scientific reports · 2018Article
- Evidence that polycystins are involved in Hydra cnidocyte discharge.Invertebrate neuroscience : IN · 2017Article
- Evolution of Protein Domain Repeats in Metazoa.Molecular biology and evolution · 2016Article
- Genomic data do not support comb jellies as the sister group to all other animals.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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6 authors.
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Abstract
Mechanoreception, the sensing of mechanical forces, is an ancient means of orientation and communication and tightly linked to the evolution of motile animals. In flies, the transient-receptor-potential N protein (TRP-N) was found to be a cilia-associated mechanoreceptor. TRP-N belongs to a large and diverse family of ion channels. Its unusually long N-terminal repeat of 28 ankyrin domains presumably acts as the gating spring by which mechanical energy induces channel gating. We analyzed the evolutionary origins and possible diversification of TRP-N. Using a custom-made set of highly discriminative sequence profiles we scanned a representative set of metazoan genomes and subsequently corrected several gene models. We find that, contrary to other ion channel families, TRP-N is remarkably conserved in its domain arrangements and copy number (1) in all Bilateria except for amniotes, even in the wake of several whole-genome duplications. TRP-N is absent in Porifera but present in Ctenophora and Placozoa. Exceptional multiplications of TRP-N occurred in Cnidaria, independently along the Hydra and the Nematostella lineage. Molecular signals of subfunctionalization can be attributed to different mechanisms of activation of the gating spring. In Hydra this is further supported by in situ hybridization and immune staining, suggesting that at least three paralogs adapted to nematocyte discharge, which is key for predation and defense. We propose that these new candidate proteins help explain the sensory complexity of Cnidaria which has been previously observed but so far has lacked a molecular underpinning. Also, the ancient appearance of TRP-N supports a common origin of important components of the nervous systems in Ctenophores, Cnidaria, and Bilateria.
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