ArticleClinical and experimental nephrology2016
Time-dependent risk factors associated with the decline of estimated GFR in CKD patients.
Article in Clinical and experimental nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Feature-based clustering of hemoglobin trajectories and subsequent risk of end-stage kidney disease in stages 3-4 CKD: a landmark analysis.Frontiers in nutrition · 2026Article
- Ethnic and immigrant disparities in dialysis prevalence and chronic kidney disease trajectories in Toronto.BMJ open · 2025Observational
- Cognitive Impairment: A Novel Risk Factor for Rapid Kidney Function Decline and Incident CKD in Middle-Aged Adults.Kidney360 · 2025Article
- Are There Any Renoprotective Effects of SGLT2 Inhibitors in Heart Transplant Recipients with Diabetes?Acta Cardiologica Sinica · 2025Article
- Predictors of decline in kidney function in the general population: a decade of follow-up from the Tehran Lipid and Glucose Study.Annals of medicine · 2023Article
- Article
- Relationship between serum cystatin-c and coronary lesion severity in coronary artery disease patients with a normal glomerular filtration rate.The Journal of international medical research · 2021Article
- Relationship between trajectory of sleep quality and short-term changes in residual renal function in stage 3-5 chronic kidney disease patients.Clinical and experimental nephrology · 2020Article
- Decline in serum uric acid predicts higher risk for mortality in peritoneal dialysis patients-a propensity score analysis.Journal of nephrology · 2020Article
- Effect of biologic drugs on renal function in psoriasis patients with chronic kidney disease.Journal of the American Academy of Dermatology · 2020Article
- Role of anemia and proteinuria in the development of subsequent renal function deterioration in a general population with preserved glomerular filtration rate: a community-based cohort study.Journal of nephrology · 2019Article
- Comparing outcomes of biopsy-proven anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis patients treated with cyclophosphamide in the 20th and 21st centuries: a 23-year study.Clinical kidney journal · 2019Article
- Statistical models for the deterioration of kidney function in a primary care population: A retrospective database analysis.F1000Research · 2019Article
- Plasma neutrophil gelatinase-associated lipocalin (NGAL) is an indicator of interstitial damage and a predictor of kidney function worsening of chronic kidney disease in the early stage: a pilot study.Clinical and experimental nephrology · 2017Article
- Posttransplantation anemia in kidney transplant recipients: A retrospective cohort study.Medicine · 2017Observational
- Time to target uric acid to retard CKD progression.Clinical and experimental nephrology · 2017Review
- The Impact of Normal Range of Serum Phosphorus on the Incidence of End-Stage Renal Disease by A Propensity Score Analysis.PloS one · 2016Article
- Targeting Uric Acid and the Inhibition of Progression to End-Stage Renal Disease--A Propensity Score Analysis.PloS one · 2015Article
- Blood pressure and phosphate level in diabetic and non-diabetic kidney disease: Results of the cross-sectional "Low Clearance Consultation" study.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTargeting the modifiable risk factors may help halt the progression of CKD, thus risk factor analysis is better performed using the parameters in the follow-up. This study aimed to examine the time-dependent risk factors for CKD progression using time-averaged values and to investigate the characteristics of rapid progression group.
methodsThis is a retrospective cohort study enrolling 770 patients of CKD stage 3-4. Time-dependent parameters were calculated as time-averaged values by a trapezoidal rule. % decline of estimated GFR (eGFR) per year from entry was divided to three groups: <10% (stable), 10-25% (moderate progression), and ≥25% (rapid progression). Multivariate regression analyses were employed for the baseline and the time-averaged datasets.
resultseGFR decline was 2.83 ± 4.04 mL/min/1.73 m(2)/year (8.8 ± 12.9 %) in male and 1.66 ± 3.23 mL/min/1.73 m(2)/year (5.4 ± 11.0%) in female (p < 0.001). % decline of eGFR was associated with male, proteinuria, phosphorus, and systolic blood pressure as risk factors and with age, albumin, and hemoglobin as protective factors using either dataset. Baseline eGFR and diabetic nephropathy appeared in the baseline dataset, while uric acid appeared in the time-averaged dataset. The rapid progression group was associated with proteinuria, phosphorus, albumin, and hemoglobin in the follow-up.
conclusionThese results suggest that time-averaged values provide insightful clinical guide in targeting the risk factors. Rapid decline of eGFR is strongly associated with hyperphosphatemia, proteinuria, and anemia indicating that these risk factors should be intervened in the follow-up of CKD.
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