ReviewCurrent opinion in neurobiology2015
Dynamic role of adult-born dentate granule cells in memory processing.
Review in Current opinion in neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Intrinsic Excitability of Rat Hippocampal Granule Cells Increases Along the Dorsal-to-Ventral Axis.Hippocampus · 2026Article
- Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus.Science advances · 2024Article
- Article
- Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps.Cell reports · 2023Article
- Assessments of dentate gyrus function: discoveries and debates.Nature reviews. Neuroscience · 2023Review
- Male Stressed Mice Having Behavioral Control Exhibit Escalations in Dorsal Dentate Adult-Born Neurons and Spatial Memory.International journal of molecular sciences · 2023Article
- Adult hippocampal neurogenesis and its impairment in Alzheimer's disease.Zoological research · 2022Review
- Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.iScience · 2022Article
- Spinal Cord Injury Leads to Hippocampal Glial Alterations and Neural Stem Cell Inactivation.Cellular and molecular neurobiology · 2022Article
- Neuromodulatory roles ofAIMS neuroscience · 2022Article
- IGF1 Gene Therapy Reversed Cognitive Deficits and Restored Hippocampal Alterations After Chronic Spinal Cord Injury.Molecular neurobiology · 2021Article
- Activation of 6-8-week-old new mature adult-born dentate granule cells contributes to anxiety-like behavior.Neurobiology of stress · 2021Article
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- Ion-channel regulation of response decorrelation in a heterogeneous multi-scale model of the dentate gyrus.Current research in neurobiology · 2021Article
- Memory-related process in physiological status and alzheimer's disease.Molecular biology reports · 2020Review
- Heterogeneities in intrinsic excitability and frequency-dependent response properties of granule cells across the blades of the rat dentate gyrus.Journal of neurophysiology · 2020Article
- Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons.Cell reports · 2020Article
- Dentate Granule Cells Recruited in the Home Environment Display Distinctive Properties.Frontiers in cellular neuroscience · 2020Article
- Disparate forms of heterogeneities and interactions among them drive channel decorrelation in the dentate gyrus: Degeneracy and dominance.Hippocampus · 2019Article
- Chronic Jet Lag Simulation Decreases Hippocampal Neurogenesis and Enhances Depressive Behaviors and Cognitive Deficits in Adult Male Rats.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Throughout the adult life of all mammals including humans, new neurons are incorporated to the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more excitable and plastic than mature ones, and they respond to a wider range of inputs. In apparent contradiction, new neurons have been shown to be crucial to solve behavioral tasks that involve the discrimination of very similar situations, which would instead require high input specificity. We propose that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space. With maturation, they would specialize to represent details of these novel inputs, favoring discrimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.