Evidence map›Paper›PMID 26100060›Full record

ArticleBMC pregnancy and childbirth2015

Pregnancy complications and birth outcomes among women experiencing nausea only or nausea and vomiting during pregnancy in the Norwegian Mother and Child Cohort Study.

Arthur Chortatos, Margaretha Haugen, Per Ole Iversen, Åse Vikanes, Malin Eberhard-Gran, Elisabeth Krefting Bjelland, Per Magnus, Marit B Veierød

Erratum issuedAbstract read
In one paragraph

Article in BMC pregnancy and childbirth, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arthur ChortatosOslo Centre for Biostatistics and Epidemiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1122, Blindern, N-0317, Oslo, Norway. athanasc@medisin.uio.no.
Margaretha HaugenDivision of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway. Margaretha.Haugen@fhi.no.
Per Ole IversenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, N-0317, Oslo, Norway. p.o.iversen@medisin.uio.no.
Åse VikanesDivision of Epidemiology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway. AseVigdis.Vikanes@fhi.no.
Malin Eberhard-GranDepartment of Psychosomatics and Health Behaviour, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway. megr@fhi.no.
Elisabeth Krefting BjellandDepartment of Psychosomatics and Health Behaviour, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway. ElisabethKrefting.Bjelland@fhi.no.
Per MagnusDivision of Epidemiology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, N-0403, Oslo, Norway. Per.Magnus@fhi.no.
Marit B VeierødOslo Centre for Biostatistics and Epidemiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1122, Blindern, N-0317, Oslo, Norway. m.b.veierod@medisin.uio.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare pregnancy complications and birth outcomes for women experiencing nausea and vomiting in pregnancy, or nausea only, with symptom-free women.

methodsPregnancies from the Norwegian Mother and Child Cohort Study (n = 51 675), a population-based prospective cohort study, were examined. Data on nausea and/or vomiting during gestation and birth outcomes were collected from three questionnaires answered between gestation weeks 15 and 30, and linked with data from the Medical Birth Registry of Norway. Chi-squared tests, one way analysis of variance, multiple linear and logistic regression analyses were used.

resultsWomen with nausea and vomiting (NVP) totalled 17 070 (33%), while 20 371 (39%) experienced nausea only (NP), and 14 234 (28%) were symptom-free (SF). When compared to SF women, NVP and NP women had significantly increased odds for pelvic girdle pain (adjusted odds ratio, aOR, 2.26, 95% confidence interval, 95% CI, 2.09-2.43, and aOR 1.90, 95% CI, 1.76-2.05, respectively) and proteinuria (aOR 1.50, 95% CI 1.38-1.63, and 1.20, 95% CI 1.10-1.31, respectively). Women with NVP also had significantly increased odds for high blood pressure (aOR 1.40, 95% CI 1.17-1.67) and preeclampsia (aOR 1.13, 95% CI 1.01-1.27). Conversely, the NVP and NP groups had significantly reduced odds for unfavourable birth outcomes such as low birth weight infants (aOR 0.72, 95% CI 0.60-0.88, and aOR 0.73, 95 % CI 0.60-0.88, respectively) and small for gestational age infants (aOR 0.78, 95% CI 0.73-0.84, and aOR 0.87, 95% CI 0.81-0.93, respectively).

conclusionsWe found that women with NVP and NP are more likely to develop pregnancy complications, yet they display mostly favourable delivery and birth outcomes.

Indexed as

AdultCase-Control StudiesCohort StudiesFemaleHumansHypertension, Pregnancy-InducedInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeLinear ModelsLogistic ModelsMorning SicknessNauseaNorwayOdds RatioPelvic Girdle Pain

Identifiers

PMID26100060
PMCPMC4477493

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.