ArticleCardiovascular ultrasound2015
Grading diastolic function by echocardiography: hemodynamic validation of existing guidelines.
Article in Cardiovascular ultrasound, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Systematic review of the evidence of cardiac dysfunction and intravenous fluid use among children with severe acute malnutrition and severe dehydration.BMJ paediatrics open · 2026Pooled it
- Artificial intelligence machine learning based evaluation of elevated left ventricular end-diastolic pressure: a Cleveland Clinic cohort study.Cardiovascular diagnosis and therapy · 2024Article
- Assessment of the diagnostic value of NT-proBNP in heart failure with preserved ejection fraction.The British journal of cardiology · 2024Article
- Hypertensive Heart Disease-The Imaging Perspective.Journal of clinical medicine · 2023Review
- Cardiac epigenetic changes in VEGF signaling genes associate with myocardial microvascular rarefaction in experimental chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023Article
- Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction.American journal of physiology. Heart and circulatory physiology · 2022Article
- Intrarenal modulation of NF-κB activity attenuates cardiac injury in a swine model of CKD: a renal-cardio axis.American journal of physiology. Renal physiology · 2021Article
- Echocardiographic assessment of fetal cardiac function in the uterine artery ligation rat model of IUGR.Pediatric research · 2021Article
- Mechanistic validation of the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging Guidelines for the assessment of diastolic dysfunction in heart failure with reduced ejection fraction.Cardiovascular ultrasound · 2020Article
- Passive leg-lifting in heart failure patients predicts exercise-induced rise in left ventricular filling pressures.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Transthoracic echocardiography compared with coronary angiography for patients with cardiogenic shock: A prospective cohort study.Experimental and therapeutic medicine · 2019Article
- Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.Trends in cardiovascular medicine · 2019Review
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile echocardiographic grading of left ventricular (LV) diastolic dysfunction (DD) is used every day, the relationship between echocardiographic DD grade and hemodynamic abnormalities is uncertain.
methodsWe identified 460 consecutive patients who underwent transthoracic echocardiography within 24 h of elective left heart catheterization and had: normal sinus rhythm, no confounding structural heart disease, no change in medications between catheterization and echo, and complete echocardiographic data. Patients were grouped based on echocardiographic DD grade. Hemodynamic tracings were used to determine time constant of isovolumic pressure decay (Tau), LV end-diastolic pressure (LVEDP) and end-diastolic volume index at a pressure of 20 mmHg (EDVi20).
resultsNormal diastolic function was found in 55 (12.0%) patients, while 132 (28.7%) patients had grade 1, 156 (33.9%) grade 2 and 117 (25.4%) grade 3 DD. The median value for Tau was 46.9 ms for the overall population (interquartile range 38.6-58.1 ms), with a prevalence of a prolonged Tau (>48 ms) of 47.5%. While there was an association between DD grade and Tau (p = 0.003), LV dysfunction (ejection fraction <50%) was more strongly associated with increased Tau (p < 0.001) than was DD grade (p = 0.19). There was also an association between DD grade and LVEDP (p < 0.001), with both LV dysfunction (p = 0.029) and DD grade (p < 0.001) independently associated with LVEDP. Calculated EDVi20 was related to DD grade, but this relationship was driven by findings of paradoxically increased compliance in patients with severe DD.
conclusionsAlthough echocardiographic grading of DD was related to invasive hemodynamics in this population, the relationship was modest.
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