Observational studyBMC nephrology2015
Association between 24-hour blood pressure variability and chronic kidney disease: a cross-sectional analysis of African Americans participating in the Jackson heart study.
Observational study in BMC nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Chronic kidney disease as a catalyst for cerebral microbleeds: understanding the underlying mechanisms and treatment approaches.Frontiers in medicine · 2025Review
- Article
- Short-term blood pressure variability as a potential therapeutic target for kidney disease.Clinical hypertension · 2023Review
- Cardiovascular variability, sociodemographics, and biomarkers of disease: the MIDUS study.Frontiers in physiology · 2023Article
- Review
- Measurement of Blood Pressure in Chronic Kidney Disease: Time to Change Our Clinical Practice - A Comprehensive Review.International journal of nephrology and renovascular disease · 2022Review
- 24-h ambulatory blood pressure variability and hypertensive nephropathy in Han Chinese hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2021Observational
- Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans.Scientific reports · 2020Article
- Short-Term Systolic Blood Pressure Variability and Kidney Disease Progression in Patients With Chronic Kidney Disease: Results From C-STRIDE.Journal of the American Heart Association · 2020Article
- Repeated ambulatory monitoring reveals an evening rise in blood pressure in a Japanese population.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Expert panel consensus recommendations for ambulatory blood pressure monitoring in Asia: The HOPE Asia Network.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Cardiovascular Disease and Mortality in Adults Aged ≥60 Years According to Recommendations by the American College of Cardiology/American Heart Association and American College of Physicians/American Academy of Family Physicians.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Central blood pressure variability is increased in hypertensive patients with target organ damage.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms.Translational stroke research · 2017Review
- Long-Term Visit-to-Visit Blood Pressure Variability and Renal Function Decline in Patients With Hypertension Over 15 Years.Journal of the American Heart Association · 2016Article
- Ambulatory Blood Pressure in Chronic Kidney Disease: Ready for Prime Time?Kidney international reports · 2016Article
- Evaluation of Renal-Hepatic Functional Indices and Blood Pressure Based on the Progress of Time in a Rat Model of Chronic Kidney Disease.Nephro-urology monthly · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high 24-h BP variability are also common among individuals with chronic kidney disease (CKD). We hypothesized 24-h BP variability would be higher for individuals with versus without CKD.
methodsWe analyzed 1,022 Jackson Heart Study participants who underwent ambulatory blood pressure monitoring (ABPM). Twenty-four hour BP variability was defined by two metrics: day-night standard deviation (SDdn) and average real variability (ARV). CKD was defined as ACR ≥ 30 mg/g or eGFR <60 mL/min/1.73 m(2).
resultsThe mean SDdn of systolic BP (SBP) was 10.2 ± 0.2 and 9.1 ± 0.1 mmHg and the mean ARV of SBP was 9.2 ± 0.2 and 8.6 ± 0.1 mmHg for those with and without CKD, respectively (each p ≤ 0.001). After adjustment for age and sex, SDdn and ARV were 0.98 mmHg (95 % CI 0.59, 1.38) and 0.52 mmHg (95 % CI 0.18, 0.86), respectively, higher among participants with versus without CKD. These differences were not statistically significant after further multivariable adjustment including 24-h mean SBP. Older age, and higher total cholesterol and 24-h mean SBP were associated with higher SDdn and ARV of SBP among participants with CKD. Mean SDdn and ARV of diastolic BP (DBP) were higher for participants with versus without CKD but these associations were not present after multivariable adjustment.
conclusionData from the current study suggest that CKD is associated with higher 24-h BP variability, but the association is primarily explained by higher mean BP among those with CKD.
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