Evidence map›Paper›PMID 26099528›Full record

ReviewContemporary clinical trials2015

Innovative designs of point-of-care comparative effectiveness trials.

Mei-Chiung Shih, Mintu Turakhia, Tze Leung Lai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Contemporary clinical trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mei-Chiung ShihVA Palo Alto Cooperative Studies Program Coordinating Center, Mountain View, CA, USA. Electronic address: mei-chiung.shih@va.gov.
Mintu TurakhiaDepartment of Medicine, Stanford University, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA.
Tze Leung LaiDepartment of Statistics, Stanford University, Stanford, CA, USA; Department of Health Research and Policy, Stanford University, Stanford, CA, USA.

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
Interim Analysis and Other Topics in BiostatisticsR01CA088890 · NCI · STANFORD UNIVERSITY · PI LAI, TZE LEUNG · 2002 to 2004
$311k
NCATS NIH HHS UL1 TR001085NCI NIH HHS R01 CA088890NCRR NIH HHS 1UL1 RR025744NCRR NIH HHS UL1 RR025744
6 · The paper itself

Abstract

One of the provisions of the health care reform legislation in 2010 was for funding pragmatic clinical trials or large observational studies for comparing the effectiveness of different approved medical treatments, involving broadly representative patient populations. After reviewing pragmatic clinical trials and the issues and challenges that have made them just a small fraction of comparative effectiveness research (CER), we focus on a recent development that uses point-of-care (POC) clinical trials to address the issue of "knowledge-action gap" in pragmatic CER trials. We give illustrative examples of POC-CER trials and describe a trial that we are currently planning to compare the effectiveness of newly approved oral anticoagulants. We also develop novel stage-wise designs of information-rich POC-CER trials under competitive budget constraints, by using recent advances in adaptive designs and other statistical methodologies.

Indexed as

Research DesignAnticoagulantsAtrial FibrillationComparative Effectiveness ResearchHumansRandom AllocationRandomized Controlled Trials as TopicAnticoagulantsAdaptive designAnticoagulantsComparative effectivenessPoint-of-care trialsPragmatic trialsShared decision making

Identifiers

PMID26099528
PMCPMC4639459

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.