ArticleIndian journal of pediatrics2015
Post Splenectomy Outcome in β-Thalassemia.
Article in Indian journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Maternal Coagulation Profiles in Pregnant Women with Thalassemia: A Retrospective Observational Study in South China.International journal of women's health · 2026Article
- Gene Therapy: A Revolutionary Step in Treating Thalassemia.Hematology reports · 2024Review
- Long-Term Health-Related Quality of Life and Clinical Outcomes in Patients with β-Thalassemia after Splenectomy.Journal of clinical medicine · 2023Article
- Splenectomy perspective for non-malignant hematological disorders: A cross-sectional study in the Eastern Province of KSA.Journal of Taibah University Medical Sciences · 2022Article
- Article
- Surgical and anaesthetic outcomes of paediatric splenectomies at a tertiary care institution in South India: a retrospective cohort.Pediatric surgery international · 2022Review
- Article
- The rare hemoglobin variant Hb Mizuho: report of a Swiss family and literature review.Annals of hematology · 2021Review
- Achievement of Pre- and Post-Transfusion Hemoglobin Levels in Adult Transfusion-Dependent Beta Thalassemia: Associated Factors and Relationship to Reduction of Spleen Enlargement.International journal of general medicine · 2021Article
- Impact of activated monocyte and endothelial dysfunction on coagulopathy in Egyptian adult beta thalassemic patients.Hematology reports · 2020Article
- Indications and Outcomes of Splenectomy for Hematological Disorders.Open medicine (Warsaw, Poland) · 2019Article
- Splenectomy for β-Thalassemia Major in Resource Challenged Settings: Often a Hobson's Choice!Indian journal of pediatrics · 2015Article
- Bacterial Infections Following Splenectomy for Malignant and Nonmalignant Hematologic Diseases.Mediterranean journal of hematology and infectious diseases · 2015Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate changes in annual blood transfusion requirements and complications after splenectomy in patients with β-thalassemia.
methodsForty post-splenectomy β-thalassemic patients aged 8-33 y, receiving regular blood transfusions and chelation therapy were included and non transfusion dependant patients were excluded from this retrospective cross-sectional study. Details about their surgery, transfusion requirements, and platelet levels were recorded on a standard proforma. All patients underwent a B-mode and color-coded duplex sonography of the hepatoportal system during the study period.
resultsThe average ferritin level in the year prior to the study was 4432 mcg/L (range 480-12,200 mcg/L). The annual blood transfusion requirement in the first year and 5 y post splenectomy [mean ± SD (138.41 ± 90.38 ml/kg/y); (116 ± 41.44 ml/kg/y)] were significantly different from requirements before splenectomy [(mean ± SD) 294.85 ± 226 ml/kg/y; p value <0.001]. There was a significant rise in platelet counts within 24 h post splenectomy with a mean rise of 4,51,000/mm(3) (p value < 0.001). During the follow up period, infections were noted in 50 % of patients, with malaria (18.75 %) being the most common. Doppler study of the portal system in one case showed portal vein thrombosis.
conclusionsA significant sustained fall in annual blood transfusion requirement and a rise in platelet counts occurred post-splenectomy. Increase in annual blood transfusion requirement should be investigated to find the cause.
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