ArticleJournal of materials science. Materials in medicine2015
The influence of SrO and CaO in silicate and phosphate bioactive glasses on human gingival fibroblasts.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 45 citations in OpenAlex.
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- Surface Modification of Bioresorbable Phosphate Glasses for Controlled Protein Adsorption.ACS biomaterials science & engineering · 2021Article
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- Impact of Glass Composition on Hydrolytic Degradation of Polylactide/Bioactive Glass Composites.Materials (Basel, Switzerland) · 2021Article
- Effects of a Novel Bioactive Glass Composition on Biological Properties of Human Dental Pulp Stem Cells.Materials (Basel, Switzerland) · 2020Article
- Chitosan-Based Bioactive Glass Gauze: Microstructural Properties, In Vitro Bioactivity, and Biological Tests.Materials (Basel, Switzerland) · 2020Article
- In vitro Evaluation of Porous borosilicate, borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regeneration.Scientific reports · 2018Article
- Influence of single and binary doping of strontium and lithium on in vivo biological properties of bioactive glass scaffolds.Scientific reports · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this paper, we investigate the effect of substituting SrO for CaO in silicate and phosphate bioactive glasses on the human gingival fibroblast activity. In both materials the presence of SrO led to the formation of a CaP layer with partial Sr substitution for Ca. The layer at the surface of the silicate glass consisted of HAP whereas at the phosphate glasses it was close to the DCPD composition. In silicate glasses, SrO gave a faster initial dissolution and a thinner reaction layer probably allowing for a continuous ion release into the solution. In phosphate glasses, SrO decreased the dissolution process and gave a more strongly bonded reaction layer. Overall, the SrO-containing silicate glass led to a slight enhancement in the activity of the gingival fibroblasts cells when compared to the SrO-free reference glass, S53P4. The cell activity decreased up to 3 days of culturing for all phosphate glasses containing SrO. Whereas culturing together with the SrO-free phosphate glass led to complete cell death at 7 days. The glasses containing SrO showed rapid cell proliferation and growth between 7 and 14 days, reaching similar activity than glass S53P4. The addition of SrO in both silicate and phosphate glasses was assumed beneficial for proliferation and growth of human gingival fibroblasts due to Sr incorporation in the reaction layer at the glass surface and released in the cell culture medium.
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