ArticleBMC infectious diseases2015
Alterations of Bacteroides sp., Neisseria sp., Actinomyces sp., and Streptococcus sp. populations in the oropharyngeal microbiome are associated with liver cirrhosis and pneumonia.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Salivary microbiome in patients with benign prostatic hyperplasia: altered composition and its association with prostate-specific antigen.BMC microbiology · 2025Article
- Oral microbiota and biliary tract cancers: unveiling hidden mechanistic links.Frontiers in oncology · 2025Review
- Oropharyngeal microbiome profiling and its association with age and heart failure in the elderly population from the northernmost province of China.Microbiology spectrum · 2024Article
- Association between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients.BMC microbiology · 2023Observational
- Human disease prediction from microbiome data by multiple feature fusion and deep learning.iScience · 2022Article
- Diurnal changes of the oral microbiome in patients with alcohol dependence.Frontiers in cellular and infection microbiology · 2022Article
- Shen-Ling-Bai-Zhu-San Enhances the Antipneumonia Effect of Cefixime in Children by Ameliorating Gut Microflora, Inflammation, and Immune Response.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Vital Members in the More Dysbiotic Oropharyngeal Microbiotas in H7N9-Infected Patients.Frontiers in medicine · 2020Article
- Oropharyngeal Microbiome in Obstructive Sleep Apnea: Decreased Diversity and Abundance.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Microbiome diurnal rhythmicity and its impact on host physiology and disease risk.EMBO reports · 2019Review
- Case report of Actinomyces turicensis meningitis as a complication of purulent mastoiditis.BMC infectious diseases · 2018Article
- Unique subgingival microbiota associated with periodontitis in cirrhosis patients.Scientific reports · 2018Article
- Comparison of Oropharyngeal Microbiota in Healthy Piglets and Piglets With Respiratory Disease.Frontiers in microbiology · 2018Article
- Metagenomics Biomarkers Selected for Prediction of Three Different Diseases in Chinese Population.BioMed research international · 2018Article
- Disordered oropharyngeal microbial communities in H7N9 patients with or without secondary bacterial lung infection.Emerging microbes & infections · 2017Article
- Microbial investigations in throat swab and tracheal aspirate specimens are beneficial to predict the corresponding endotracheal tube biofilm flora among intubated neonates with ventilator-associated pneumonia.Experimental and therapeutic medicine · 2017Article
- Motif-Based Text Mining of Microbial Metagenome Redundancy Profiling Data for Disease Classification.BioMed research international · 2016Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe microbiomes of humans are associated with liver and lung inflammation. We identified and verified alterations of the oropharyngeal microbiome and assessed their association with cirrhosis and pneumonia.
methodsStudy components were as follows: (1) determination of the temporal stability of the oropharyngeal microbiome; (2) identification of oropharyngeal microbial variation in 90 subjects; (3) quantitative identification of disease-associated bacteria. DNAs enriched in bacterial sequences were produced from low-biomass oropharyngeal swabs using whole genome amplification and were analyzed using denaturing gradient gel electrophoresis analysis.
resultsWhole genome amplification combined with denaturing gradient gel electrophoresis analysis monitored successfully oropharyngeal microbial variations and showed that the composition of each subject's oropharyngeal microbiome remained relatively stable during the follow-up. The microbial composition of cirrhotic patients with pneumonia differed from those of others and clustered together in subgroup analysis. Further, species richness and the value of Shannon's diversity and evenness index increased significantly in patients with cirrhosis and pneumonia versus others (p < 0.001, versus healthy controls; p < 0.01, versus cirrhotic patients without pneumonia). Moreover, we identified variants of Bacteroides, Eubacterium, Lachnospiraceae, Neisseria, Actinomyces, and Streptococcus through phylogenetic analysis. Quantitative polymerase chain reaction assays revealed that the populations of Bacteroides, Neisseria, and Actinomycetes increased, while that of Streptococcus decreased in cirrhotic patients with pneumonia versus others (p < 0.001, versus Healthy controls; p < 0.01, versus cirrhotic patients without pneumonia).
conclusionsAlterations of Bacteroides, Neisseria, Actinomyces, and Streptococcus populations in the oropharyngeal microbiome were associated with liver cirrhosis and pneumonia.
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