ArticleScientific reports2015
Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.Communications medicine · 2026Article
- Functional connectome fingerprinting related to BMI and its association with impulsivity.Brain imaging and behavior · 2025Article
- The Neuro-Endo-Microbio-Ome Study: A Pilot Study of Neurobiological Alterations Pre- Versus Post-Bariatric Surgery.Biological research for nursing · 2022Article
- Connectome-Based Prediction of Optimal Weight Loss Six Months After Bariatric Surgery.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Changes in brain activity after weight loss.Obesity science & practice · 2019Article
- Article
- Prefrontal gray matter volume mediates genetic risks for obesity.Molecular psychiatry · 2017Article
- Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study.Frontiers in psychology · 2017Article
- Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers.International journal of obesity (2005) · 2016Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity as a chronic disease is a major factor for insulin resistance and Type 2 diabetes, which has become a global health problem. In the present study, we used resting state functional MRI to investigate the amplitude of low frequency fluctuations of spontaneous signal during both hunger and satiety states in 20 lean and 20 obese males. We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects. Furthermore, after food intake, obese males had significantly lesser activity in dACC than lean males. We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake. These results indicated that both precuneus and dACC may play an important role in eating behavior. While precuneus rather seemed to mediate subjective satiety, dACC levels rather reflected indirect measures of glucose utilization.
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