ArticlePloS one2015
Analysis of Multiple Brachyspira hyodysenteriae Genomes Confirms That the Species Is Relatively Conserved but Has Potentially Important Strain Variation.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Genomic insights into the population structure, antimicrobial resistance, and virulence ofMicrobiology spectrum · 2025Article
- Improving the consistency of experimental swine dysentery inoculation strategies.Veterinary research · 2023Article
- Article
- Whole-genome analyses reveal a novel prophage and cgSNPs-derived sublineages of Brachyspira hyodysenteriae ST196.BMC genomics · 2022Article
- Experimental natural transmission (seeder pig) models for reproduction of swine dysentery.PloS one · 2022Article
- Whole-Genome Sequencing ofFrontiers in microbiology · 2021Article
- Evidence of homologous recombination as a driver of diversity inMicrobial genomics · 2020Article
- Differential expression of hemolysin genes in weakly and strongly hemolytic Brachyspira hyodysenteriae strains.BMC veterinary research · 2020Article
- Hiding in Plain Sight: Colonic Spirochetosis in Humans.Journal of bacteriology · 2019Article
- Weakly haemolytic variants of Brachyspira hyodysenteriae newly emerged in Europe belong to a distinct subclade with unique genetic properties.Veterinary research · 2019Article
- Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance inFrontiers in microbiology · 2018Article
- Article
- An avirulent Brachyspira hyodysenteriae strain elicits intestinal IgA and slows down spread of swine dysentery.Veterinary research · 2017Article
- Article
- Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs.Veterinary research · 2016Article
- The Exposed Proteomes of Brachyspira hyodysenteriae and B. pilosicoli.Frontiers in microbiology · 2016Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal spirochete Brachyspira hyodysenteriae is an important pathogen in swine, causing mucohemorrhagic colitis in a disease known as swine dysentery. Based on the detection of significant linkage disequilibrium in multilocus sequence data, the species is considered to be clonal. An analysis of the genome sequence of Western Australian B. hyodysenteriae strain WA1 has been published, and in the current study 19 further strains from countries around the world were sequenced with Illumina technology. The genomes were assembled and aligned to over 97.5% of the reference WA1 genome at a percentage sequence identity better than 80%. Strain regions not aligned to the reference ranged between 0.2 and 2.5%. Clustering of the strain genes found on average 2,354 (88%) core genes, 255 (8.6%) ancillary genes and 77 (2.9%) unique genes per strain. Depending on the strain the proportion of genes with 100% sequence identity to WA1 ranged from 85% to 20%. The result is a global comparative genomic analysis of B. hyodysenteriae genomes revealing potential differential phenotypic markers for numerous strains. Despite the differences found, the genomes were less varied than those of the related pathogenic species Brachyspira pilosicoli, and the analysis supports the clonal nature of the species. From this study, a public genome resource has been created that will serve as a repository for further genetic and phenotypic studies of these important porcine bacteria. This is the first intra-species B. hyodysenteriae comparative genomic analysis.
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