Trial reportEmotion (Washington, D.C.)2015
Blocking opioids attenuates physical warmth-induced feelings of social connection.
Trial report in Emotion (Washington, D.C.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Endogenous mu-opioid modulation of social connection in humans: a systematic review and meta-analysis.Translational psychiatry · 2024Pooled it
- Opioids and social bonding: Effect of naltrexone on feelings of social connection and ventral striatum activity to close others.Journal of experimental psychology. General · 2020Trial
- Naltrexone alters responses to social and physical warmth: implications for social bonding.Social cognitive and affective neuroscience · 2019Trial
- Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans.Hormones and behavior · 2018Trial
- Trial
- Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?Physiology (Bethesda, Md.) · 2024Review
- Physical and social warmth.Royal Society open science · 2024Article
- TheFrontiers in psychology · 2024Article
- Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia.Schizophrenia bulletin · 2023Review
- Shifting the sociometer: opioid receptor blockade lowers self-esteem.Social cognitive and affective neuroscience · 2023Article
- Does Problematic Use of Social Network Mediate the Association between Bullying Victimization and Loneliness among Lebanese Adolescents?Children (Basel, Switzerland) · 2023Article
- Only empathy-related traits, not being mimicked or endorphin release, influence social closeness and prosocial behavior.Scientific reports · 2023Article
- Sensory Stimuli to Sustainable Social Wellbeing: A Multimodal Approach Based on Warm Scent.Behavioral sciences (Basel, Switzerland) · 2022Article
- Editorial: Human Connection as a Treatment for Addiction.Frontiers in psychology · 2022Article
- Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives.Frontiers in behavioral neuroscience · 2022Review
- Opposing effects of antibiotics and germ-free status on neuropeptide systems involved in social behaviour and pain regulation.BMC neuroscience · 2020Article
- A novel theory on the predictive value of variation in the β-endorphin system on the risk and severity of PTSD.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2020Review
- Anhedonia as a key clinical feature in the maintenance and treatment of opioid use disorder.Clinical psychological science : a journal of the Association for Psychological Science · 2019Article
- Taking rejection to heart: Associations between blood pressure and sensitivity to social pain.Biological psychology · 2018Article
- Modernizing Relationship Therapy through Social Thermoregulation Theory: Evidence, Hypotheses, and Explorations.Frontiers in psychology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
"Heartwarming" social experiences, when one feels interpersonally connected to others, have recently been linked with physical warmth. According to one theory (Panksepp, 1998), "social warmth" and physical warmth may be closely linked because both experiences are supported by similar neurobiological mechanisms; however, the neurochemical substrates underlying this overlap have not been explored. Here, an opioid antagonist, naltrexone, was administered in order to examine the role of opioids, previously shown to alter temperature and social bonding behavior, on perceived thermal intensity, general positive affect, and feelings of social connection from physical warmth. Thirty-one participants took both naltrexone and a placebo and completed a temperature manipulation task (held a warm pack, cold pack, and neutral object) while on each drug. Replicating previous research, holding a warm (vs. a cold or neutral) object increased feelings of social connection. Moreover, blocking opioids reduced this effect. Hence, naltrexone specifically reduced feelings of social connection to holding a warm (vs. neutral) object but not to holding a cold (vs. neutral) object. These results lend further support to the theory that social and physical warmth share neurobiological, opioid receptor dependent mechanisms.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.