Evidence map›Paper›PMID 26098683›Full record

SynthesisPloS one2015

In vitro Anti-Tumor Effects of Statins on Head and Neck Squamous Cell Carcinoma: A Systematic Review.

Ludmila Madeira Cardoso Pavan, Daniela Fortunato Rêgo, Silvia Taveira Elias, Graziela De Luca Canto, Eliete Neves Silva Guerra

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ludmila Madeira Cardoso PavanLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil.
Daniela Fortunato RêgoLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil.
Silvia Taveira EliasLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil.
Graziela De Luca CantoDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil, and University of Alberta, Edmonton, Canada.
Eliete Neves Silva GuerraLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStatins are commonly used against arteriosclerotic disease, but recent retrospective analyses have suggested that statins also prevent cancer. The aim of this systematic review is to verify the vitro anti-tumor effects of statins on head and neck squamous cell carcinoma.

methodsStudies were gathered by searching Cochrane, MEDLINE, EMBASE, LILACS, and PubMed, up until May 9, 2015, with no time or language restrictions. Only in vitro studies that discuss the effect of statins on head and neck carcinoma were selected.

resultsOf 153 identified papers, 14 studies met the inclusion criteria. These studies demonstrated that statins had a significant effect on head and neck squamous cell carcinoma cell lines and influenced cell viability, cell cycle, cell death, and protein expression levels involved in pathways of carcinogenesis, which corroborates with the potential in vitro anti-tumor effects. It provides highlights about the biological mechanisms of statins used alone or associated with traditional therapy for cancer.

conclusionsThough there are few studies on the topic, currently available evidence suggests that statins shows that preclinical experiments supports the potentiality of statin as an adjuvant agent in chemotherapy and/or radiotherapy approaches routinely used in the management of HNSCC and should undergo further clinical assessment.

Indexed as

Antineoplastic AgentsCarcinoma, Squamous CellCell Line, TumorHead and Neck NeoplasmsHeLa CellsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMCF-7 CellsRandomized Controlled Trials as TopicSquamous Cell Carcinoma of Head and NeckAntineoplastic AgentsHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID26098683
PMCPMC4476585

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.