ArticleRadiology2015
Incidence of Internal Mammary Lymph Nodes with Silicone Breast Implants at MR Imaging after Oncoplastic Surgery.
Article in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Thoracic approach for suspected internal mammary lymph node recurrence following mastectomy and implant-based reconstruction: a case report.Journal of surgical case reports · 2025Article
- Internal mammary lymph nodal response to neoadjuvant chemotherapy on imaging and breast cancer prognosis.Annals of medicine and surgery (2012) · 2022Article
- Internal mammary lymph node metastasis in breast cancer patients based on anatomical imaging and functional imaging.Breast cancer (Tokyo, Japan) · 2022Review
- Management of MRI-Detected Benign Internal Mammary Lymph Nodes.The Indian journal of radiology & imaging · 2022Article
- Recurrent Metastatic Breast Cancer in Internal Mammary Lymph Nodes along the Translocated Left Internal Mammary Artery Bypass Graft.Radiology. Cardiothoracic imaging · 2021Article
- Progressive silicone lymphadenopathy post mastectomy and implant reconstruction for breast cancer.BMJ case reports · 2021Article
- Incidence of benign and malignant peri-implant fluid collections and masses on magnetic resonance imaging in women with silicone implants.Cancer medicine · 2020Article
- Internal mammary lymph node metastases in breast cancer: what should radiologists know?Japanese journal of radiology · 2018Review
- Imaging findings of mammary and systemic silicone deposition secondary to breast implants.The British journal of radiology · 2018Review
- Internal mammary lymph nodes radiotherapy of breast cancer in the era of individualized medicine.Oncotarget · 2017Review
- Silicone Implant Incompatibility Syndrome: Mimicking Metastases on Fluoro-Deoxy-Glucose Positron Emission Tomography-Computed Tomography in a Treated Case of Carcinoma Breast.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo assess the incidence of benign and malignant internal mammary lymph nodes (IMLNs) at magnetic resonance (MR) imaging among women with a history of treated breast cancer and silicone implant reconstruction. MATERIALS AND
methodsThe institutional review board approved this HIPAA-compliant retrospective study and waived informed consent. Women were identified who (a) had breast cancer, (b) underwent silicone implant oncoplastic surgery, and (c) underwent postoperative implant-protocol MR imaging with or without positron emission tomography (PET)/computed tomography (CT) between 2000 and 2013. The largest IMLNs were measured. A benign IMLN was pathologically proven or defined as showing 1 year of imaging stability and/or no clinical evidence of disease. Malignant IMLNs were pathologically proven. Incidence of IMLN and positive predictive value (PPV) were calculated on a per-patient level by using proportions and exact 95% confidence intervals (CIs). The Wilcoxon rank sum test was used to assess the difference in axis size.
resultsIn total, 923 women with breast cancer and silicone implants were included (median age, 46 years; range, 22-89 years). The median time between reconstructive surgery and first MR imaging examination was 49 months (range, 5-513 months). Of the 923 women, 347 (37.6%) had IMLNs at MR imaging. Median short- and long-axis measurements were 0.40 cm (range, 0.20-1.70 cm) and 0.70 cm (range, 0.30-1.90 cm), respectively. Two hundred seven of 923 patients (22.4%) had adequate follow-up; only one of the 207 IMLNs was malignant, with a PPV of 0.005 (95% CI: 0.000, 0.027). Fifty-eight of 923 patients (6.3%) had undergone PET/CT; of these, 39 (67.2%) had IMLN at MR imaging. Twelve of the 58 patients (20.7%) with adequate follow-up had fluorine 18 fluorodeoxyglucose-avid IMLN, with a median standardized uptake value of 2.30 (range, 1.20-6.10). Only one of the 12 of the fluorodeoxyglucose-avid IMLNs was malignant, with a PPV of 0.083 (95% CI: 0.002, 0.385).
conclusionIMLNs identified at implant-protocol breast MR imaging after oncoplastic surgery for breast cancer are overwhelmingly more likely to be benign than malignant. Imaging follow-up instead of immediate metastatic work-up may be warranted.
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