Trial reportPain2015
Altered pain modulation in patients with persistent postendodontic pain.
Trial report in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05142228 (Erenumab as a Therapeutic Approach for the Management of Trigeminal Neuropathic Pain), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Erenumab as a Therapeutic Approach for the Management of Trigeminal Neuropathic Pain (TNP)
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Effect of intracanal cryotherapy application on postoperative endodontic pain: a systematic review and metaanalysis.Clinical oral investigations · 2021Pooled it
- Effects of intensity of electroacupuncture on chronic pain in patients with knee osteoarthritis: a randomized controlled trial.Arthritis research & therapy · 2019Trial
- Doxazosin Alleviates Chronic Orofacial Pain.International journal of molecular sciences · 2026Article
- Pressure point: blood flow restriction exercise and the pain paradox in musculoskeletal injury and persistent pain populations-a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- The effects of socioeconomic position on endogenous pain modulation: A quasi-experimental approach.The journal of pain · 2025Article
- Article
- The Endogenous Pain Modulatory System as a Healing Mechanism: A Proposal on How to Measure and Modulate It.NeuroSci · 2024Review
- Post-traumatic Trigeminal Neuropathy Associated With Endodontic Therapy: A Systematic Review.Cureus · 2022Review
- Pathophysiology of Post-Traumatic Trigeminal Neuropathic Pain.Biomolecules · 2022Review
- Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients.The journal of headache and pain · 2022Article
- Can Intra-Oral Qualitative Sensory Testing Foretell Postoperative Dental Pain? A Preliminary Report.International journal of environmental research and public health · 2022Article
- Pretreatment with High Mobility Group Box-1 Monoclonal Antibody Prevents the Onset of Trigeminal Neuropathy in Mice with a Distal Infraorbital Nerve Chronic Constriction Injury.Molecules (Basel, Switzerland) · 2021Article
- Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.Comprehensive Physiology · 2021Article
- Brainstem Pain-Modulation Circuitry and Its Plasticity in Neuropathic Pain: Insights From Human Brain Imaging Investigations.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies.Frontiers in molecular neuroscience · 2021Review
- Persistent dentoalveolar pain disorder: A putative intraoral chronic overlapping pain condition.Oral diseases · 2020Review
- Amygdala, neuropeptides, and chronic pain-related affective behaviors.Neuropharmacology · 2020Review
- Chronic orofacial pain.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Age and gender differences in mechanically induced intraoral temporal summation and conditioned pain modulation in healthy subjects.Oral surgery, oral medicine, oral pathology and oral radiology · 2018Article
- Experimental evidence for weaker endogenous inhibition of trigeminal pain than extra-trigeminal pain in healthy individuals.Cephalalgia : an international journal of headache · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Persistent pain may follow nerve injuries associated with invasive therapeutic interventions. About 3% to 7% of the patients remain with chronic pain after endodontic treatment, and these are described as suffering from painful posttraumatic trigeminal neuropathy (PTTN). Unfortunately, we are unable to identify which patients undergoing such procedures are at increased risk of developing PTTN. Recent findings suggest that impaired endogenous analgesia may be associated with the development of postsurgical chronic pain. We hypothesized that patients with PTTN display pronociceptive pain modulation, in line with other chronic pain disorders. Dynamic (conditioned pain modulation, temporal summation) and static (response to mechanical and cold stimulation) psychophysical tests were performed intraorally and in the forearm of 27 patients with PTTN and 27 sex- and age-matched controls. The dynamic sensory testing demonstrated less efficient conditioned pain modulation, suggesting reduced function of the inhibitory endogenous pain-modulatory system, in patients with PTTN, mainly in those suffering from the condition for more than a year. The static sensory testing of patients with PTTN demonstrated forearm hyperalgesia to mechanical stimulation mainly in patients suffering from the condition for less than a year and prolonged painful sensation after intraoral cold stimulus mainly in patients suffering from the condition for more than a year. These findings suggest that PTTN is associated more with the inhibitory rather than the facilitatory arm of pain modulation and that the central nervous system has a role in PTTN pathophysiology, possibly in a time-dependent fashion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.