Trial reportPloS one2015
Vitamin B12 and Folic Acid Improve Gross Motor and Problem-Solving Skills in Young North Indian Children: A Randomized Placebo-Controlled Trial.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian Children
Supplementation of Vitamin B12 in Pregnancy and Postpartum on Growth and Cognitive Functioning in Early Childhood: A Randomized, Placebo Controlled Trial
Vitamin B12 Status in Infancy and the Effect of Providing Vitamin B12 to Infants With Signs of Suboptimal Vitamin B12 Status - a Registry-based, Randomized Controlled Trial
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Vitamin B12 supplementation for growth, development, and cognition in children.The Cochrane database of systematic reviews · 2026Pooled it
- The Effect of Vitamin B-12 Supplementation During Pregnancy on Early Motor Performance: Secondary Analyses From a Double-Blinded Randomized Controlled Trial.The Journal of nutrition · 2026Trial
- Vitamin B12 and Folate Status in Pregnant Females and Their Infants in Norway: Secondary Analysis from the Mommy's Food Study.The Journal of nutrition · 2023Trial
- Serum cobalamin in children with moderate acute malnutrition in Burkina Faso: Secondary analysis of a randomized trial.PLoS medicine · 2022Trial
- Effects of vitamin B12 supplementation on neurodevelopment and growth in Nepalese Infants: A randomized controlled trial.PLoS medicine · 2020Trial
- Does early vitamin BBMJ open · 2018Trial
- Trial
- The effect of vitamin BTrials · 2017Trial
- Association between the Infant and Child Feeding Index at 8 months and early childhood neurodevelopment.Frontiers in nutrition · 2025Article
- Anemia, Growth Impairment, and Micronutrients Status in Syrian Children Aged 12-60 Months.International journal of pediatrics · 2025Article
- The benefits of nurturing care interventions on early child development and care: findings from a quasi-experimental study in a humanitarian setting.BMC pediatrics · 2023Article
- Vitamin BBMJ open · 2023Article
- Associations between Early Life Nutrient Intakes and Brain Maturation Show Developmental Dynamics from Infancy to Toddlerhood: A Neuroimaging Observation Study.The Journal of nutrition · 2023Observational
- Relationship between Animal Sourced Food Consumption and Early Childhood Development Outcomes.Nutrients · 2023Article
- The silent tragic reality ofThe Lancet regional health. Southeast Asia · 2022Review
- Article
- Low vitamin B-12-high folate status in adolescents and pregnant women may have deleterious effects on health of the offspring.The American journal of clinical nutrition · 2021Article
- Pre-conceptional Maternal Vitamin B12 Supplementation Improves Offspring Neurodevelopment at 2 Years of Age: PRIYA Trial.Frontiers in pediatrics · 2021Article
- Potential for elimination of folate and vitamin BBMJ nutrition, prevention & health · 2021Article
- Vitamin B-12 Supplementation during Pregnancy and Early Lactation Does Not Affect Neurophysiologic Outcomes in Children Aged 6 Years.The Journal of nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
objectivesDeficiencies of vitamin B12 and folate are associated with delayed development and neurological manifestations. The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children.
methodsIn a randomized, double blind trial, children aged six to 30 months, received supplement with placebo or vitamin B12 and/or folic acid for six months. Children were allocated in a 1:1:1:1 ratio in a factorial design and in blocks of 16. We measured development in 422 children by the Ages and Stages Questionnaire 3rd ed. at the end of the intervention.
resultsCompared to placebo, children who received both vitamin B12 and folic acid had 0.45 (95% CI 0.19, 0.73) and 0.28 (95% CI 0.02, 0.54) higher SD-units in the domains of gross motor and problem solving functioning, respectively. The effect was highest in susceptible subgroups consisting of stunted children, those with high plasma homocysteine (> 10 μmol/L) or in those who were younger than 24 at end study. With the exception of a significant improvement on gross motor scores by vitamin B12 alone, supplementation of either vitamin alone had no effect on any of the outcomes.
conclusionOur findings suggest that supplementation of vitamin B12 and folic acid benefit development in North Indian Children.
trial registrationClinicalTrials.gov NCT00717730.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.