ArticleJournal of consulting and clinical psychology2015
Association between physical pain and alcohol treatment outcomes: The mediating role of negative affect.
Article in Journal of consulting and clinical psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02423772 (Pilot Study of Combined Treatment for Veterans With Chronic Pain & Opiate Misuse), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of Combined Treatment for Veterans With Chronic Pain & Opiate Misuse
Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
- Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue-provoked pain responses in individuals with alcohol use disorder.Experimental and clinical psychopharmacology · 2026Trial
- Examining changes in pain interference via pandemic-induced isolation among patients receiving medication for opioid use disorder: a secondary data analysis.BMC public health · 2024Trial
- Opioid Misuse as a Predictor of Alcohol Treatment Outcomes in the COMBINE Study: Mediation by Medication Adherence.Alcoholism, clinical and experimental research · 2018Trial
- Alcohol use disorder-associated pain: clinical and preclinical evidence.Alcohol (Fayetteville, N.Y.) · 2025Review
- Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Associations of physical pain, alcohol use, and related factors in the daily lives of patients with chronic low back pain.Alcohol (Fayetteville, N.Y.) · 2025Article
- The association between pain and negative alcohol-related consequences among college students engaged in binge drinking: The moderating role of reward and relief drinking motives.Addictive behaviors · 2025Article
- Affect-laden risk profiles derived from two days of EMA predict substance use and quality of life three- and six-months after SUD treatment.Journal of substance use and addiction treatment · 2025Article
- Pain and unhealthy alcohol use among people living with HIV: A prospective cohort study.Alcohol, clinical & experimental research · 2024Article
- Insomnia treatment effects on negative emotionality among veterans in treatment for alcohol use disorder.Alcohol, clinical & experimental research · 2024Article
- Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking.Translational psychiatry · 2024Article
- Pain in alcohol use disorder: Evaluating effects of childhood trauma, perceived stress, and psychological comorbidity.Alcohol (Fayetteville, N.Y.) · 2024Article
- Pain Predicts Dropout From Substance Use Treatment.Journal of studies on alcohol and drugs · 2024Article
- Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic.The American journal of psychiatry · 2024Review
- Deficits in proactive avoidance and neural responses to drinking motives in problem drinkers.Research square · 2024Article
- Within and Beyond the Binary: Sex and Gender Differences in Pain and Alcohol Use Disorder.Current addiction reports · 2024Article
- Long-lasting mechanical hypersensitivity and CRF receptor type-1 neuron activation in the BNST following adolescent ethanol exposure.Alcohol, clinical & experimental research · 2024Article
- Neural and Psychosocial Mechanisms Underlying Alcohol Use and Pain Interactions: Overview of Current Evidence and Future Directions.Current addiction reports · 2023Article
- Sex-specific biobehavioral regulation of persistent inflammatory pain by alcohol.Alcohol, clinical & experimental research · 2023Article
- Longitudinal associations between pain and substance use disorder treatment outcomes.Journal of substance abuse treatment · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivePhysical pain and negative affect have been described as risk factors for alcohol use following alcohol treatment. The current study was a secondary analysis of 2 clinical trials for alcohol use disorder (AUD) to examine the associations between pain, negative affect and AUD treatment outcomes.
methodParticipants included 1,383 individuals from the COMBINE Study (COMBINE Pharmacotherapies and Behavioral Interventions for Alcohol Dependence; COMBINE Study Research Group, 2003; 31% female, 23% ethnic minorities, average age = 44.4 [SD = 10.2]), a multisite combination pharmacotherapy and behavioral intervention study for AUD in the United States, and 742 individuals from the United Kingdom Alcohol Treatment Trial (UKATT Research Team, 2001; 25.9% female, 4.4% ethnic minorities, average age = 41.6 [SD = 10.1]) a multisite behavioral intervention study for AUD in the United Kingdom. The Form-90 was used to collect alcohol use data, the Short Form Health Survey and Quality of Life measures were used to assess pain, and negative affect was assessed using the Brief Symptom Inventory (COMBINE) and the General Health Questionnaire (UKATT).
resultsPain scores were significantly associated with drinking outcomes in both datasets. Greater pain scores were associated with greater negative affect and increases in pain were associated with increases in negative affect. Negative affect significantly mediated the association between pain and drinking outcomes and this effect was moderated by social behavior network therapy (SBNT) in the UKATT study, with SBNT attenuating the association between pain and drinking.
conclusionFindings suggest pain and negative affect are associated among individuals in AUD treatment and that negative affect mediated pain may be a risk factor for alcohol relapse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.