ArticleNature2015
Redox rhythm reinforces the circadian clock to gate immune response.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
108 citing papers in PubMed, 211 citations in OpenAlex.
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- Circadian oscillations in chromatin accessibility systematically orchestrate rhythmic gene transcription in soybean.The Plant cell · 2026Article
- Leaf it to science: Uncovering plant immune systems through technological advances.Plant physiology · 2026Review
- Autonomous Redox Rhythms and Their Coupling to the Circadian Clock.Advances in experimental medicine and biology · 2026Review
- Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time.Life metabolism · 2025Review
- Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude inLife science alliance · 2025Article
- Genome-wide identification of the WRKY transcription factors family and regulation of metabolites under cold stress in Astragalus membranaceus.BMC plant biology · 2025Article
- Gating of immune-triggered cell death is a redox rhythm-specific output.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Primary metabolism determines the outcome of salicylic acid-mediated immune induction.bioRxiv : the preprint server for biology · 2025Article
- The redox rhythm gates immune-induced cell death distinctly from the genetic clock.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Experimentally Guided Iterative Parameter Estimation for Predictive Chemical Oscillator Models.Angewandte Chemie (International ed. in English) · 2025Article
- Drought recovery in plants triggers a cell-state-specific immune activation.Nature communications · 2025Article
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- Metabolism in Sync: The Circadian Clock, a Central Hub for Light-Driven Chloroplastic and Mitochondrial Entrainment.Plants (Basel, Switzerland) · 2025Review
- Transcript profiling of plastid ferrochelatase two mutants reveals that chloroplast singlet oxygen signals lead to global changes in RNA profiles and are mediated by Plant U-Box 4.BMC plant biology · 2025Article
- In vivo dynamics of indole- and phenol-derived plant hormones: Long-term, continuous, and minimally invasive phytohormone sensor.Science advances · 2025Article
- Diurnal dynamics of different circadian transcription modules in Chinese pine needles and roots during dormancy induction.BMC plant biology · 2025Article
- Alternaria alternata effector AaAlta1 targets CmWD40 and participates in regulating disease resistance in Chrysanthemum morifolium.PLoS pathogens · 2025Article
- Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing HCell research · 2025Article
- A splicing regulator, SR45, suppresses plant immunity by regulating salicylic acid pathway inFrontiers in plant science · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies have shown that in addition to the transcriptional circadian clock, many organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism's metabolic activities. It has been hypothesized that the redox rhythm is linked to the circadian clock, but the mechanism and the biological significance of this link have only begun to be investigated. Here we report that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant's redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge. Surprisingly, acute perturbation in the redox status triggered by the immune signal salicylic acid does not compromise the circadian clock but rather leads to its reinforcement. Mathematical modelling and subsequent experiments show that NPR1 reinforces the circadian clock without changing the period by regulating both the morning and the evening clock genes. This balanced network architecture helps plants gate their immune responses towards the morning and minimize costs on growth at night. Our study demonstrates how a sensitive redox rhythm interacts with a robust circadian clock to ensure proper responsiveness to environmental stimuli without compromising fitness of the organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.