ArticlePLoS computational biology2015
High Stimulus-Related Information in Barrel Cortex Inhibitory Interneurons.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Spiking neural networks provide accurate and time-efficient models for whisker stimulus classification of the awake mouse.Frontiers in neuroscience · 2026Article
- Dynamics of neocortical networks: connectivity beyond the canonical microcircuit.Pflugers Archiv : European journal of physiology · 2023Review
- Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex.Frontiers in cellular neuroscience · 2023Article
- Neocortical inhibitory interneuron subtypes are differentially attuned to synchrony- and rate-coded information.Communications biology · 2021Article
- Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo.Scientific reports · 2021Article
- Assessing the Impact of Single-Cell Stimulation on Local Networks in Rat Barrel Cortex-A Feasibility Study.International journal of molecular sciences · 2019Article
- Single-Cell Stimulation in Barrel Cortex Influences Psychophysical Detection Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Optogenetic Modulation of a Minor Fraction of Parvalbumin-Positive Interneurons Specifically Affects Spatiotemporal Dynamics of Spontaneous and Sensory-Evoked Activity in Mouse Somatosensory Cortex in Vivo.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- A Theory of How Columns in the Neocortex Enable Learning the Structure of the World.Frontiers in neural circuits · 2017Article
- Sex differences in endogenous cortical network activity: spontaneously recurring Up/Down states.Biology of sex differences · 2017Article
- Inhibitory Circuits in Cortical Layer 5.Frontiers in neural circuits · 2016Review
- Dynamics of Population Activity in Rat Sensory Cortex: Network Correlations Predict Anatomical Arrangement and Information Content.Frontiers in neural circuits · 2016Article
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Authors and funding
6 authors.
Funding
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Abstract
The manner in which populations of inhibitory (INH) and excitatory (EXC) neocortical neurons collectively encode stimulus-related information is a fundamental, yet still unresolved question. Here we address this question by simultaneously recording with large-scale multi-electrode arrays (of up to 128 channels) the activity of cell ensembles (of up to 74 neurons) distributed along all layers of 3-4 neighboring cortical columns in the anesthetized adult rat somatosensory barrel cortex in vivo. Using two different whisker stimulus modalities (location and frequency) we show that individual INH neurons--classified as such according to their distinct extracellular spike waveforms--discriminate better between restricted sets of stimuli (≤6 stimulus classes) than EXC neurons in granular and infra-granular layers. We also demonstrate that ensembles of INH cells jointly provide as much information about such stimuli as comparable ensembles containing the ~20% most informative EXC neurons, however presenting less information redundancy - a result which was consistent when applying both theoretical information measurements and linear discriminant analysis classifiers. These results suggest that a consortium of INH neurons dominates the information conveyed to the neocortical network, thereby efficiently processing incoming sensory activity. This conclusion extends our view on the role of the inhibitory system to orchestrate cortical activity.
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