ArticlePloS one2015
Customized Finite Element Modelling of the Human Cornea.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 92 citations in OpenAlex.
- Revolutionizing vision using corneal 3D printing.Trends in biotechnology · 2026Review
- Preoperative Corneal Astigmatic Direction is Associated with Stromal Mechanical Anisotropy in SMILE-Derived Lenticules.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Advances in 3D Bioprinting for Corneal Regeneration.Gels (Basel, Switzerland) · 2025Review
- Corneal viscoelasticity is associated with intraocular pressure under physiological baseline: insights from the rheological properties of corneal lenticules.Frontiers in bioengineering and biotechnology · 2025Article
- Unraveling the impact of laser refractive surgery on corneal ectasia: anFrontiers in bioengineering and biotechnology · 2025Article
- Influence of Contact Lens Parameters on Cornea: Biomechanical Analysis.Bioengineering (Basel, Switzerland) · 2024Article
- Contact lens fitting and changes in the tear film dynamics: mathematical and computational models review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
- Establishing Standardization Guidelines For Finite-Element Optomechanical Simulations of Refractive Laser Surgeries: An Application to Photorefractive Keratectomy.Translational vision science & technology · 2024Article
- Study of the Influence of Boundary Conditions on Corneal Deformation Based on the Finite Element Method of a Corneal Biomechanics Model.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- Review
- Biomechanics of keratoconus: Two numerical studies.PloS one · 2023Article
- Optical coherence elastography for assessing the influence of intraocular pressure on elastic wave dispersion in the cornea.Journal of the mechanical behavior of biomedical materials · 2022Article
- The combined importance of finite dimensions, anisotropy, and pre-stress in acoustoelastography.The Journal of the Acoustical Society of America · 2022Review
- Estimations of Critical Clear Corneal Incisions Required for Lens Insertion in Cataract Surgery: A Mathematical Aspect.Frontiers in physiology · 2022Article
- Effects of LaserFrontiers in bioengineering and biotechnology · 2022Article
- Individualized Characterization of the Distribution of Collagen Fibril Dispersion Using Optical Aberrations of the Cornea for Biomechanical Models.Investigative ophthalmology & visual science · 2020Article
- Theoretical Analysis of Wave-Front Aberrations Induced from Conventional Laser Refractive Surgery in a Biomechanical Finite Element Model.Investigative ophthalmology & visual science · 2020Article
- Cornea modelling.Eye and vision (London, England) · 2020Article
- Novel dynamic corneal response parameters in a practice use: a critical review.Biomedical engineering online · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo construct patient-specific solid models of human cornea from ocular topographer data, to increase the accuracy of the biomechanical and optical estimate of the changes in refractive power and stress caused by photorefractive keratectomy (PRK).
methodCorneal elevation maps of five human eyes were taken with a rotating Scheimpflug camera combined with a Placido disk before and after refractive surgery. Patient-specific solid models were created and discretized in finite elements to estimate the corneal strain and stress fields in preoperative and postoperative configurations and derive the refractive parameters of the cornea.
resultsPatient-specific geometrical models of the cornea allow for the creation of personalized refractive maps at different levels of IOP. Thinned postoperative corneas show a higher stress gradient across the thickness and higher sensitivity of all geometrical and refractive parameters to the fluctuation of the IOP.
conclusionPatient-specific numerical models of the cornea can provide accurate quantitative information on the refractive properties of the cornea under different levels of IOP and describe the change of the stress state of the cornea due to refractive surgery (PRK). Patient-specific models can be used as indicators of feasibility before performing the surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.