Evidence map›Paper›PMID 26097808›Full record

ArticleCurrent opinion in insect science2015

Heterochromatin, histone modifications, and nuclear architecture in disease vectors.

Igor V Sharakhov, Maria V Sharakhova

Abstract read
In one paragraph

Article in Current opinion in insect science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Regulation of chromatin organization during animal regeneration.Cell regeneration (London, England) · 2023
    Review
  3. Impact ofInternational journal of molecular medicine · 2022
    Article
  4. Article
  5. Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Igor V SharakhovDepartment of Entomology, Virginia Tech, Blacksburg, Virginia, USA.
Maria V SharakhovaDepartment of Entomology, Virginia Tech, Blacksburg, Virginia, USA ; Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia.
Virginia Tech · US

Funding

Chromosome-based genome assembly for Culex quinquefasciatusR21AI101345 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SHARAKHOVA, MARIA · 2013 to 2014
$450k
Physical mapping of Aedes aegypti genomeR21AI088035 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SHARAKHOVA, MARIA · 2010 to 2011
$433k
Improving the reference genome assembly for the dengue fever vector Aedes aegyptiR21AI121853 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SHARAKHOVA, MARIA · 2016 to 2017
$423k
Highly finished chromosome-based genome assembly for Anopheles gambiaeR21AI094289 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SHARAKHOV, IGOR V · 2011 to 2012
$420k
Comparative genome mapping of the Anopheles species clusterR21AI099528 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SHARAKHOV, IGOR V · 2014 to 2015
$419k
NIAID NIH HHS R21 AI088035NIAID NIH HHS R21 AI094289NIAID NIH HHS R21 AI099528NIAID NIH HHS R21 AI101345NIAID NIH HHS R21 AI121853
6 · The paper itself

Abstract

Interactions between a pathogen and a vector are plastic and dynamic. Such interactions can be more rapidly accommodated by epigenetic changes than by genetic mutations. Gene expression can be affected by the proximity to the heterochromatin, by local histone modifications, and by the three-dimensional position within the nucleus. Recent studies of disease vectors indicate that gene regulation by these factors can be important for susceptibility to pathogens, reproduction, immunity, development, and longevity. Knowledge about heterochromatin, histone modifications, and nuclear architecture will help our understanding of epigenetic mechanisms that control gene function at traits related to vectorial capacity.

Identifiers

PMID26097808
PMCPMC4470418
OpenAlexW1528318068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.